Carbohydrate Research p. 39 - 50 (1994)
Update date:2022-08-06
Topics: Synthesis Biological activities Analogue
Chung, Sung-Kee
Moon, Sung-Hwan
The synthesis of the α and β anomers of the title compound (1) was accomplished from D-mannose.In the key step, the phosphonate analogues of the mannopyranosyl phosphates were prepared by a direct Wadsworth-Emmons condensation of a protected mannose derivative (8) with tetraethyl methylenebisphosphonate under two-phase conditions.In vitro bioassays have shown that the β-anomer (1a) is a potent inhibitor of Ins(1,4,5)P3 3- kinase and inhibits other enzymes.
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