New diastereoselective synthesis of protected meso-lanthionine with discrimination of the chiral centers

Article abstract of DOI:10.1016/S0957-4166(00)82315-0

A synthesis of meso-lanthionine with discrimination of the chiral centers is reported. Two cysteine residues of opposite configuration and with orthogonal protections are temporarily and reversibly linked in order to promote the formation of an intramolecular disulfide bridge thus avoiding symmetrization reactions during the sulfur extrusion step.