Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents

DOI: 10.1016/S0968-0896(97)00058-8

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1345 - 1361 (1997)

Update date:2022-08-04

Topics:

Authors:

Li, Hui-Yin

DeLucca, Indawati

Boswell, George A.

Billheimer, Jeffrey T.

Drummond, Spencer

Gillies, Peter J.

Robinson, Candy

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Article abstract of DOI:10.1016/S0968-0896(97)00058-8

Novel 4,4-bis(trifluoromethyl)imidazolines have been found to be the potent acyl-CoA cholesterol acyltransferase (ACAT) inhibitors. ACAT is responsible for cholesterol esterification in the intestine, liver, and the arterial wall. These novel imidazolines

Full text of DOI:10.1016/S0968-0896(97)00058-8

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Product name:4-fluoro-N-[2-(4-fluorophenyl)-3,5-dihydro-5,5-bis(trifluoromethyl)-4H-imidazol-4-ylidene]benzamide

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