Cationic ruthenium catalysts for alkyne annulations with oximes by C-H/N-O functionalizations

Article abstract of DOI:10.1021/jo301768b

Cationic ruthenium(II) complexes enabled efficient redox-neutral annulations of alkynes with readily available oximes. The catalytic dehydrative C-H/N-O bond functionalization proved to be broadly applicable and was shown to proceed through a reversible cyclometalation.

Full text of DOI:10.1021/jo301768b

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Article
Cationic Ruthenium Catalysts for Alkyne Annulations
with Oximes by C–H/N–O Functionalizations
Christoph Kornhaaß, Jie Li, and Lutz Ackermann
J. Org. Chem., Just Accepted Manuscript • Publication Date (Web): 17 Sep 2012
Downloaded from http://pubs.acs.org on September 18, 2012
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Cationic Ruthenium Catalysts for Alkyne
Annulations with Oximes by C–H/N–O
Functionalizations
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Christoph Kornhaaß, Jie Li, and Lutz Ackermann*
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2,
37077 Göttingen, Germany
Lutz.Ackermann@chemie.uni-goettingen.de
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RECEIVED DATE
Title running head: Cationic Ruthenium Catalysts for Alkyne Annulations with Oximes
R2
H
R2
R3
R4
OH
cat. [Ru]
- H2O
N
N
R1
R1
+
R4
R3
Abstract: Cationic ruthenium(II) complexes enabled efficient redox-neutral annulations of alkynes with
readily available oximes. The catalytic dehydrative C–H/N–O bond functionalization proved to be
broadly applicable, and was shown to proceed through a reversible cyclometalation.
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Introduction
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The modular assembly of regioselectively decorated heterocycles is of central importance because of
their prevalence in natural products and drugs.1 Particularly, isoquinolines are key building blocks in
organic synthesis, and represent structural motifs of alkaloids with, among others, cardiovascular, anti-
inflammatory or anti-malarial bioactivities.2 As a result, there is a continued strong demand for versatile
isoquinoline syntheses. While transition metal-catalyzed annulations with prefunctionalized ortho-halo-
substituted benzimines were previously developed,3 a more atom- and step-economical strategy was
realized with methods that capitalize upon C–H4 bond activation. Hence, the research groups of Jun,
Bergman and Ellman, Cheng, Fagnou, Satoh and Miura, Chiba, Rovis as well as Li exploited chelation
assistance for rhodium-catalyzed5 isoquinoline and pyridine syntheses.6
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In 2011, we reported on the use of less-expensive ruthenium7 complexes for oxidative annulations of
alkynes by benzamides through C–H/N–H bond cleavages.8 Notably, this approach proved more
generally applicable.9 Indeed, ruthenium(II) biscarboxylates4b also set the stage for redox-neutral
dehydrative annulations of alkynes with free hydroxamic acids through C–H/N–O functionalizations to
furnish isoquinolones (Scheme 1a).10
Scheme 1. Ruthenium-Catalyzed C–H/N–O Functionalizations
(a) previous work: hydroxamic acid10
Me
i-Pr
O
H
O
cat.
R2
R3
Ru
O
H
H
RCO2
R
N
O
N
R1
R1
+
OH
- H2O
R3
R2
R2
(b) this work: oximes
R2
R3
R4
N
cat. [Ru]
- H2O
N
R1
+
R1
OH
H
R4
R3
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In consideration of the important bioactivities of substituted isoquinolines,1-3 we consequently became
attracted by utilizing ruthenium(II) complexes for step-economical isoquinoline syntheses in the
absence of external oxidants (Scheme 1b), the results of which we report herein. In contrast to previous
studies,9,10 we observed a remarkably high catalytic activity of carboxylate-free11 cationic ruthenium(II)
catalysts and obtained detailed mechanistic insight on reversible cyclometalations in dehydrative
isoquinoline syntheses.
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Results and Discussion
We initiated our studies by exploring representative metal carboxylates and solvents for the
envisioned dehydrative annulation of alkyne 2a by oxime 1a (Table 1). Among various cocatalytic
additives, KPF6 gave rise to the most satisfactory results (entries 1–9),12 while MeOH proved to be the
solvent of choice for the dehydrative annulation (entries 9–12). However, [RuBr2(p-cymene)]2 delivered
the desired isoquinoline 3aa in a reduced yield as compared to a reaction with [RuCl2(p-cymene)]2 as
the catalyst (entries 9, and 13). The high catalytic activity exerted by the KPF6-derived ruthenium
catalyst was suggestive of an in-situ formation of a cationic ruthenium(II) species (vide infra).
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Table 1. Optimization of C–H/N–O Functionalizationa
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8
9
[RuCl2(p-cymene)]2
(5.0 mol %)
additive (30 mol %)
Me
Me
Ph
OH
N
N
+
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solvent, 60 °C, 24 h
Ph
H
Ph
Ph
3aa
1a
2a
entry
1
additive
AgOAc
CuOAc
CsOAc
NaOAc
KOPiv
K2CO3
AgSbF6
NaPF6
KPF6
solvent
MeOH
MeOH
MeOH
MeOH
MeOH
MeOH
MeOH
MeOH
MeOH
MeOH
t-AmOH
H2O
yield
9%
2
13%b
61%
39%
15%
9%b
3
4
5
6
7
38%
67%
81%
83%c
9%b
8
9
10
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12
13
KPF6
KPF6
KPF6
30%
60%d
KPF6
MeOH
a
Reaction conditions: 1a (0.50 mmol), 2a (1.00 mmol), [RuCl2(p-cymene)]2 (5.0 mol %), additive
(30 mol %), solvent (2 mL), 60 °C, isolated yields. GC-conversion. 4 Å-Mol. sieves (100 mg).
[RuBr2(p-cymene)]2 (5.0 mol %).
b
c
d
Subsequently, we explored the scope of the optimized cationic ruthenium(II) complex in the redox-
neutral annulation of alkynes 2 (Scheme 2). Thus, a variety of differently substituted isoquinolines 3ba–
3ea bearing valuable electrophilic functional groups was chemoselectively accessed. Furthermore,
oximes 1 bearing sterically more demanding substituents furnished the desired products 3fa–3ma, as
did bicyclic substrate 1n. The catalytic system was not restricted to tolane (2a), but allowed for the
efficient conversion of different aryl- and alkyl-substituted alkynes 2b–2f as well. Intramolecular
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competition experiments with meta-substituted arenes 1o and 1p revealed a significant change in site-
selectivity. Thus, isoquinoline 3oa was generated through steric interactions, while oxime 1p displaying
a secondary directing group was functionalized at the sterically more congested C–2 position.
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Scheme 2. Scope of Redox-Neutral Annulation with Oximes 1
R2
[RuCl2(p-cymene)]2
(5.0 mol %)
KPF6 (30 mol %)
R2
R3
OH
N
N
R1
R1
+
MeOH, 60 °C, 24 h
R3
H
R3
R3
1
2
3
Me
Et
N
R2
N
N
R1
Ph
R1
Ph
Ph
Ph
Ph
Ph
2
R1 = Me (3ba):
R1 = CF3 (3ca):
R1 = Br (3da):
3fa
1
3ia
89%
R = n-Pr ( ):
85%
65%
54%a
R = H (
):
91%
2
1
3ja
R = n-Bu ( ):
89%
3ga 95%
R = OMe (
):
R2 = n-Pent (3ka):
R1 = F (3ha):
96%
82%
84%a
57%
R2 = Ph (3la):
1
3ea
):
R = Ph (
54%
2
3ma
R = c-Pr (
):
Me
Me
Me
N
N
N
Ph
R3
R3
Ph
R4
R4
R = Et (
3
3na
: 93%
3ad
):
86%
4
3
3ab 53%
R = OMe ( ):
3ae
R = n-Pr (
): 87%
): 79%
R4 = F (3ac):
70%
3
3af
R = n-Bu (
Me
Me
N
Me
N
Ph
Ph
O
Ph
3oa: 81%
a In the presence of 4Å-Mol. sieves.
O
Ph
3pa: 86%
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Importantly, intermolecular dehydrative annulations with challenging unsymmetrical alkynes 2
occurred with excellent regioselectivities (Scheme 3).13 Hence, the cationic ruthenium(II) complex
furnished the 3-aryl-substituted isoquinolines 3ag–3aq with high yields. Moreover, the catalyst proved
tolerant of useful functional groups, such as esters, ketones, free hydroxyl groups as well as aryl and
alkyl halides.
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Scheme 3. Scope with Unsymmetrical Alkynes 2
[RuCl2(p-cymene)]2
(5.0 mol %)
KPF6 (30 mol %)
Me
Me
R1
OH
N
N
+
MeOH, 60 °C, 24 h
H
R2
R2
R1
1a
2
3
Me
Me
N
Me
N
N
Ph
R
Me
n-Bu
Ac
R
3ag
R = Me (
R = Et (
): 69%
3aj: 70%
R = Me (3ak):
R = Ph (3al):
68%
51%
): 57%
3ah
):
63%
52%
R = n-Hex (3ai):
3am
R = OMe (
R = F (3an):
60%
R = CO2Et (3ao): 47%
Me
Me
N
N
Ph
Ph
OH
Cl
3ap: 73%
3aq
: 67%
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Given the remarkable efficacy of the in-situ generated ruthenium(II) catalyst, we subsequently probed
the performance of preformed cationic complex [Ru2Cl3(p-cymene)2][PF6] (4)12,14 (Scheme 4).
Importantly, well-defined complex 4 displayed an activity as well as chemo-, regio- and site-selectivity
being comparable to the one displayed by the in-situ formed catalytic system.
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Scheme 4. Well-Defined Cationic Complex 4 as the Catalyst
R2
R2
R3
[Ru2Cl3(p-cymene)2][PF6]
4 (5.0 mol %)
OH
N
N
R1
R1
+
MeOH, 60 °C, 24 h
R4
H
R4
R3
1
2
3
Me
Ph
Et
N
n-Bu
N
N
Me
Ph
F
Ph
Ph
Ph
Ph
Ph
Ph
3ba
: 80%
3ha: 60%
3ja
: 86%
Me
Me
Me
Me
N
N
N
n-Pr
Ph
O
n-Pr
3ae: 77%
O
Ph
Ph
3oa
3pa
: 86%
: 77%
Me
N
Cl
3aq: 72%
Mechanistic Studies. Considering the high catalytic efficacy exerted by the optimized cationic
catalyst, we became interested in delineating its mode of action. To this end, we performed
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intermolecular competition experiments between different alkynes 2, which revealed electron-deficient
5
6
substrates to be more reactive (Scheme 5).
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Scheme 5. Competition Experiment with Alkynes 2
Me
N
Ph
1a
[RuCl2(p-cymene)]2
(5.0 mol %)
KPF6 (30 mol %)
Ph
n-Pr
Ph
2aa: 54%
+
+
MeOH, 60 °C, 24 h
Me
n-Pr
Ph
N
2a
2e
(4.0 equiv) (4.0 equiv)
n-Pr
n-Pr
2ae: 32%
Moreover, intermolecular competition experiments with para-substituted oximes 1 highlighted
electron-rich arenes to be preferentially converted (Scheme 6).
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Scheme 6. Intermolecular Competition Experiments
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Me
Me
N
(a)
OH
N
2a
F3C
Ph
Ph
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F3C
MeO
F3C
Me
H
[RuCl2(p-cymene)]2
(5.0 mol %)
KPF6 (30 mol %)
Ph
3ca: 5%
1c (1.1 equiv)
+
+
Me
Me
MeOH, 60 °C, 24 h
OH
N
N
H
MeO
Ph
1q (1.1 equiv)
3qa: 38%
Me
Me
N
(b)
OH
N
H
F3C
Ph
Ph
Ph
as above
1c
3ca
(1.1 equiv)
+
: 7%
+
Me
Me
OH
N
N
H
Me
Ph
3ba: 29%
1b (1.1 equiv)
Mechanistic studies with deuterated solvent [D]4-MeOH and isotopically labeled substrate [D]5-1a
showed a significant H/D scrambling, albeit solely occurring in the presence of an alkyne (Scheme 7).
These observations were, hence, indicative of a reversible C–H bond metalation step by an alkyne-
coordinated ruthenium complex, likely proceeding through base assistance. It is further noteworthy that
deuterium was also incorporated into the methyl6f,15 group of product [D]n-3ae when using [D5]-MeOH
as the solvent (Scheme 7b).
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Scheme 7. Reactions with [D4]-MeOH and Substrate [D5]-1a
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9
< 5% D
(a)
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[RuCl2(p-cymene)]2
(5.0 mol %)
KPF6 (30 mol %)
H
Me
H
Me
H
OH
OH
N
N
CD3OD, 60 °C, 24 h
92%
H
1a
1a
15% D
(b)
[RuCl2(p-cymene)]2
(5.0 mol %)
KPF6 (30 mol %)
H
Me
H(D) CHxD3-x
N
n-Pr
OH
N
+
CD3OD, 60 °C, 24 h
76%
n-Pr
H
n-Pr
n-Pr
3ae
1a
2e
[D]n-
(x = 1.3)
(c)
16% H
[RuCl2(p-cymene)]2
(5.0 mol %)
KPF6 (30 mol %)
D
D
Me
D
(H/D) Me
n-Pr
D
OH
D
D
N
N
+
MeOH, 60 °C, 24 h
91%
n-Pr
D
n-Pr
D
n-Pr
1a
[D]5-
3ae
2e
[D]n-
Based on these mechanistic studies we propose a catalytic cycle to involve an initial reversible base-
assisted cycloruthenation with an alkyne-coordinated cationic complex, furnishing metalacycle 5,
presumably, via a SEAr-type mechanism (Scheme 8). Subsequent migratory insertion of the alkyne 2
generates key intermediate 6, while reductive elimination delivers product 3. Finally, reoxidation by the
internal oxidant via N–O bond cleavage regenerates the catalytically active species.
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Scheme 8. Proposed Catalytic Cycle
6
7
8
9
R2
R1
R2
OH
N
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N
R1
+ H2O
+
R4
H
R3
R3
3
1
[Ru]
2
H
H
R2
OH
R3
N
R2
[Ru]
OH
N
R2
[Ru]
R3
5
R2
6
Conclusions
In summary, we have reported on ruthenium-catalyzed redox-neutral annulations of alkynes by oximes
through C–H/N–O functionalizations. Contrary to previous studies,9,10 carboxylate-free cationic
ruthenium(II) catalysts were found to be most effective, which allowed for an expedient isoquinoline
synthesis via reversible cyclometalation.
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Experimental Section
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General remarks. Catalytic reactions were carried out under a N2 atmosphere using pre-dried
glassware. H2O was degassed and purged with N2, DMF was dried and distilled over CaH2, t-AmOH
was dried and distilled over sodium, MeOH was dried and distilled over Mg(OMe)2. All ketoximes 1
were synthesized according to a previously described procedure.16 Internal alkynes 2 were prepared
according to previously described methods and were purified via Kugelrohr distillation.17,18 [Ru2Cl3(p-
cymene)2][PF6] (4) was synthesized according to a previously reported procedure.12 Other chemicals
were obtained from commercial sources and were used without further purification. Yields refer to
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1
isolated compounds, estimated to be > 95% pure as determined by H-NMR and GC-analysis. NMR
spectra were recorded in the solvent indicated; chemical shifts (δ) are given in ppm. High resolution
mass spectrometry (HRMS): FTICR.
Representative procedure for the Ruthenium-Catalyzed Synthesis of Isochinolines via Direct
C‒H/N‒O Bond Functionalization, Synthesis of 1-Methyl-3,4-diphenylisoquinoline (3aa): A
mixture of acetophenone oxime (1a) (68 mg, 0.50 mmol), diphenylacetylene (2a) (178 mg, 1.00 mmol),
[RuCl2(p-cymene)]2 (15.3 mg, 0.025 mmol, 5.0 mol %), and KPF6 (28 mg, 0.15 mmol, 30 mol %) in
MeOH (2.00 mL) was stirred at 60 °C for 24 h. At ambient temperature, EtOAc (15 mL) was added and
the solvents were removed in vacuo. Purification of the remaining residue by column chromatography
(n-hexane/EtOAc: 10/1) yielded 3aa (119 mg, 81%) as a white solid (M.p.: 152–155 °C). 1H-NMR (300
MHz, CDCl3): δ = 8.23–8.20 (m, 1H), 7.71–7.67 (m, 1H), 7.63–7.57 (m, 2H), 7.44–7.32 (m, 5H), 7.29–
13
7.17 (m, 5H), 3.11 (s, 3H). C-NMR (75 MHz, CDCl3): δ = 157.7 (Cq), 149.4 (Cq), 141.0 (Cq), 137.6
(Cq), 136.0 (Cq), 131.4 (CH), 130.2 (CH), 129.9 (CH), 129.1 (Cq), 128.1 (CH), 127.6 (CH), 127.1 (CH),
126.9 (CH), 126.5 (CH), 126.2 (CH), 126.1 (Cq), 125.5 (CH), 22.7 (CH3). IR (ATR): 3025, 1567, 1389,
1334, 1072, 1026, 765, 695, 612, 563, 496 cm-1. MS (EI) m/z (relative intensity) 295 (50) [M+], 294
(100), 278 (5), 252 (17), 177 (15), 146 (6), 43 (14). HR-MS (EI): m/z calcd for C22H17N 295.1361,
found 295.1348. The spectral data are in accordance with those reported in the literature.19
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1,6-Dimethyl-3,4-diphenylisoquinoline (3ba): The representative procedure was followed using 1b
(75 mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 10/1) yielded 3ba (131 mg, 85%) as a white solid (M.p.: 160–
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163 °C). H-NMR (300 MHz, CDCl3): δ = 8.09 (d, J = 9.2 Hz, 1H), 7.44–7.39 (m, 2H), 7.39–7.30 (m,
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5H), 7.25–7.14 (m, 5H), 3.05 (s, 3H), 2.43 (s, 3H). C-NMR (75 MHz, CDCl3): δ = 157.3 (Cq), 149.5
(Cq), 141.1 (Cq), 140.1 (Cq), 137.7 (Cq), 136.2 (Cq), 131.4 (CH), 130.2 (CH), 128.7 (Cq), 128.6 (CH),
128.1 (CH), 127.5 (CH), 127.0 (CH), 126.8 (CH), 125.4 (CH), 125.0 (CH), 124.5 (Cq), 22.6 (CH3), 22.1
(CH3). IR (ATR): 3062, 1495, 1444, 1385, 1336, 1071, 1029, 813, 767, 755, 696, 614 cm-1. MS (EI) m/z
(relative intensity) 309 (40) [M+], 308 (100), 293 (5), 265 (5), 252 (12), 146 (5), 43 (4). HR-MS (ESI):
m/z calcd for C23H19N+H+ 310.1590, found 310.1592. The spectral data are in accordance with those
reported in the literature.19
6-(Trifluoromethyl)-1-methyl-3,4-diphenylisoquinoline (3ca): The representative procedure was
followed using 1c (102 mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification
by column chromatography (n-hexane/EtOAc: 12/1) yielded 3ca (118 mg, 65%) as an orange solid
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(M.p.: 109–114 °C). H-NMR (300 MHz, CDCl3): δ = 8.31 (d, J = 8.8 Hz, 1H), 7.96 (d, J = 1.8 Hz,
1H), 7.75 (dd, J = 8.8, 1.8 Hz, 1H), 7.40–7.33 (m, 5H), 7.23–7.16 (m, 5H), 3.10 (s, 3H). 13C-NMR
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(75 MHz, CDCl3): δ = 157.8 (Cq), 150.9 (Cq), 140.4 (Cq), 136.5 (Cq), 135.4 (Cq), 131.5 (q, JC–
F = 32 Hz, Cq), 131.2 (CH), 130.2 (CH), 129.7 (Cq), 128.5 (CH), 127.7 (CH), 127.6 (CH), 127.3 (CH),
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127.0 (Cq), 126.8 (CH), 123.9 (q, JC–F = 5 Hz, CH), 123.8 (d, 1JC–F = 272 Hz, Cq), 122.2 (q, JC–F = 3
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Hz, CH), 22.8 (CH3). F-NMR (282 MHz, CDCl3): δ = –62.9 (s). IR (ATR): 2958, 1555, 1336, 1305,
1257, 1176, 1155, 1134, 1082, 909, 769, 696, 618 cm-1. MS (EI) m/z (relative intensity) 363 (50) [M+],
362 (100), 252 (8), 146 (5), 43 (5). HR-MS (EI): m/z calcd for C23H16F3N 363.1235, found 363.1219.
The spectral data are in accordance with those reported in the literature.20
6-Bromo-1-methyl-3,4-diphenylisoquinoline (3da): The representative procedure was followed using
1d (107 mg, 0.50 mmol) diphenylacetylene (2a) (178 mg, 1.00 mmol) and molecular sieves 4Å
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(100 mg). Purification by column chromatography (n-hexane/EtOAc: 20/1) yielded 3da (102 mg, 54%)
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as a yellow solid (M.p.: 193–195 °C). H-NMR (300 MHz, CDCl3): δ = 8.06 (d, J = 8.9 Hz, 1H), 7.80
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(d, J = 2.0 Hz, 1H), 7.67 (dd, J = 8.9, 2.0 Hz, 1H), 7.39–7.30 (m, 5H), 7.23–7.14 (m, 5H), 3.06 (s, 3H).
13C-NMR (75 MHz, CDCl3): δ = 157.6 (Cq), 150.5 (Cq), 140.5 (Cq), 137.3 (Cq), 136.7 (Cq), 131.2 (CH),
130.0 (CH), 129.9 (CH), 128.3 (CH), 128.3 (CH), 128.2 (Cq), 127.6 (CH), 127.4 (CH), 127.2 (CH),
127.1 (CH), 125.0 (Cq), 124.5 (Cq), 22.8 (CH3). IR (ATR): 3064, 1597, 1561, 1481, 1445, 1386, 1329,
1259, 1071, 1029, 751, 697 cm-1. MS (EI) m/z (relative intensity) 374 (100) [M+H+], 293 (26), 252 (28),
189 (15), 146 (14), 43 (56). HR-MS (ESI): m/z calcd for C22H16BrN+H+ 374.0539, found 374.0538. The
spectral data are in accordance with those reported in the literature.20
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1-Methyl-3,4,6-triphenylisoquinoline (3ea): The representative procedure was followed using 1e (106
mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 15/1) yielded 3ea (101 mg, 54%) as a pale orange solid (M.p.: 176–
178 °C). 1H-NMR (300 MHz, CDCl3): δ = 8.28 (dd, J = 8.2, 1.1 Hz, 1H), 7.87 (s, 1H), 7.86 (d, J = 8.2,
1.8 Hz 1H), 7.62–7.53 (m, 2H), 7.49–7.14 (m, 14H), 3.11 (s, 3H). 13C-NMR (75 MHz, CDCl3): δ =
157.5 (Cq), 150.0 (Cq), 142.5 (Cq), 141.0 (Cq), 140.4 (Cq), 137.5 (Cq), 136.3 (Cq), 131.4 (CH), 130.2
(CH), 129.3 (Cq), 128.9 (CH), 128.2 (CH) 127.9 (CH), 127.6 (CH), 127.5 (CH), 127.2 (CH), 126.9
(CH), 126.2 (CH), 126.2 (CH), 125.2 (Cq), 124.0 (CH), 22.7 (CH3). IR (ATR): 3058, 1611, 1567, 1434,
1339, 955, 893, 831, 760, 751, 690, 611 cm-1. MS (EI) m/z (relative intensity) 371 (68) [M+], 370 (100),
354 (3), 327 (5), 292 (2), 252 (4), 77 (3). HR-MS (EI): m/z calcd for C28H21N 371.1674, found
371.1657. The spectral data are in accordance with those reported in the literature.20
1-Ethyl-3,4-diphenylisoquinoline (3fa): Representative procedure A was followed using 1f (75 mg,
0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column chromatography
(n-hexane/EtOAc: 15/1) yielded 3fa (141 mg, 91%) as a pale brown solid (M.p.: 113–115 °C). 1H-NMR
(300 MHz, CDCl3): δ = 8.29–8.20 (m, 1H), 7.70–7.62 (m, 1H), 7.61–7.50 (m, 2H), 7.42–7.30 (m, 5H),
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7.26–7.12 (m, 5H), 3.44 (q, J = 7.6 Hz, 2H), 1.53 (t, J = 7.6 Hz, 3H). C-NMR (75 MHz, CDCl3): δ =
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162.2 (Cq), 149.2 (Cq), 141.1 (Cq), 137.7 (Cq), 136.3 (Cq), 131.4 (CH), 130.3 (CH), 129.7 (CH), 128.9
(Cq), 128.2 (CH), 127.5 (CH), 127.1 (CH), 126.8 (CH), 126.4 (CH), 126.4 (CH), 125.3 (Cq), 125.1
(CH), 28.8 (CH2), 13.9 (CH3). IR (ATR): 2935, 1552, 1445, 1382, 1260, 1072, 1028, 753, 694, 607, 561
cm-1. MS (EI) m/z (relative intensity) 309 (55) [M+], 308 (100), 293 (14), 280 (8), 252 (5), 146 (5), 69
(6). HR-MS (EI): m/z calcd for C23H19N 309.1517, found 309.1505. The spectral data are in accordance
with those reported in the literature.19
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1-Ethyl-6-methoxy-3,4-diphenylisoquinoline (3ga): The representative procedure was followed using
1g (94 mg, 0.52 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 12/1) yielded 3ga (168 mg, 95%) as a pale yellow solid (M.p.: 158–
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161 °C). H-NMR (300 MHz, CDCl3): δ = 8.14 (d, J = 9.2 Hz, 1H), 7.40–7.28 (m, 5H), 7.26–7.11 (m,
6H), 6.91 (d, J = 2.6 Hz, 1H), 3.71 (s, 3H), 3.37 (q, J = 7.6 Hz, 2H), 1.50 (t, J = 7.6 Hz, 3H). 13C-NMR
(75 MHz, CDCl3): δ = 161.6 (Cq), 160.3 (Cq), 150.0 (Cq), 141.3 (Cq), 138.4 (Cq), 138.0 (Cq), 131.3
(CH), 130.3 (CH), 128.3 (Cq), 128.2 (CH), 127.5 (CH), 127.0 (CH), 127.0 (CH), 126.8 (CH), 121.0
(Cq), 119.0 (CH), 104.6 (CH), 55.1 (CH3), 28.8 (CH2), 14.1 (CH3). IR (ATR): 2970, 1617, 1574, 1454,
1411, 1232, 1146, 1018, 757, 699, 662, 527 cm-1. MS (EI) m/z (relative intensity) 339 (55) [M+], 338
(100), 323 (5), 295 (10), 280 (12), 267 (7), 239 (8). HR-MS (EI): m/z calcd for C24H21NO 339.1623,
found 339.1613.
1-Ethyl-6-fluoro-3,4-diphenylisoquinoline (3ha): The representative procedure was followed using 1h
(83 mg, 0.50 mmol) and diphenyl acetylene (2a) (178 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 15/1 → 12/1) yielded 3ha (94 mg, 57%) as a white solid (M.p.:
141–142 °C). 1H-NMR (300 MHz, CDCl3): δ = 8.27 (dd, J = 9.2, 5.7 Hz, 1H), 7.45–7.10 (m, 12H), 3.42
(q, J = 7.5 Hz, 2H), 1.53 (t, J = 7.5 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 163.0 (d, 1JC–F = 245 Hz,
Cq), 162.0 (Cq), 150.7 (Cq), 140.8 (Cq), 138.4 (d, 3JC–F = 10 Hz, Cq), 137.3 (Cq), 131.2 (CH), 130.3 (CH),
128.7 (d, 4JC–F = 5 Hz, Cq), 128.4 (CH), 128.2 (d, 3JC–F = 10 Hz, CH), 127.6 (CH), 127.3 (CH), 127.1
(CH), 122.5 (d, 4JC–F = 1 Hz, Cq), 116.6 (d, 2JC–F = 25 Hz, CH), 110.0 (d, 2JC–F = 22 Hz, CH), 28.9 (CH2),
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13.9 (CH3). 19F-NMR (282 MHz, CDCl3): δ = –107.9 (s). IR (ATR): 2973, 1619, 1573, 1447, 1386,
1182, 1072, 876, 788, 753, 697 cm-1. MS (EI) m/z (relative intensity) 327 (53) [M+], 326 (100), 311
(12), 298 (10), 98 (10), 74 (6), 57 (10), 43 (20). HR-MS (ESI): m/z calcd for C23H18FN+H+ 328.1496,
found 328.1498.
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3,4-Diphenyl-1-n-propylisoquinoline (3ia): The representative procedure was followed using 1i
(82 mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 50/1) yielded 3ia (144 mg, 89%) as a yellow solid (M.p.: 118–
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120 °C). H-NMR (300 MHz, CDCl3): δ = 8.23–8.14 (m, 1H), 7.64–7.56 (m, 1H), 7.54–7.45 (m, 2H),
7.37–7.22 (m, 5H), 7.20–7.05 (m, 5H), 3.32 (t, J = 7.7 Hz, 2H), 1.95 (dt, J = 7.7, 7.3 Hz 2H), 1.08 (t,
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J = 7.3 Hz, 3H). C-NMR (75 MHz, CDCl3): δ = 161.3 (Cq), 149.3 (Cq), 141.1 (Cq), 137.8 (Cq), 136.3
(Cq), 131.4 (CH), 130.3 (CH), 129.6 (CH), 128.9 (Cq), 128.2 (CH), 127.5 (CH), 127.5 (CH), 127.1
(CH), 126.9 (CH), 126.3 (CH), 125.6 (Cq), 125.2 (CH), 37.7 (CH2), 23.2 (CH2), 14.5 (CH3). IR (ATR):
3063, 2962, 1612, 1568, 1550, 1444, 1385, 1087, 1031, 757, 697 cm-1. MS (EI) m/z (relative intensity)
323 (22) [M+], 295 (100), 308 (16), 252 (7). HR-MS (EI): m/z calcd for C24H21N-H+ 322.1596, found
322.1607.
1-n-Butyl-3,4-diphenylisoquinoline (3ja): The representative procedure was followed using 1j (89 mg,
0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column chromatography
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(n-hexane/EtOAc: 40/1) yielded 3ja (151 mg, 89%) as a yellow solid (M.p.: 78–80 °C). H-NMR (300
MHz, CDCl3): δ = 8.27–8.21 (m, 1H), 7.69–7.64 (m, 1H), 7.60–7.54 (m, 2H), 7.40–7.31 (m, 5H), 7.26–
7.15 (m, 5H), 3.42 (t, J = 8.0 Hz, 2H), 2.02–1.90 (m, 2H), 1.58 (dt, J = 7.7, 7.3 Hz, 2H), 1.04 (t, J = 7.3
Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 161.5 (Cq), 149.3 (Cq), 141.1 (Cq), 137.7 (Cq), 136.3 (Cq),
131.4 (CH), 130.3 (CH), 129.6 (CH), 128.8 (Cq), 128.2 (CH), 127.5 (CH), 127.5 (CH), 127.0 (CH),
126.8 (CH), 126.3 (CH), 125.4 (Cq), 125.2 (CH), 35.5 (CH2), 32.1 (CH2), 23.1 (CH2), 14.1 (CH3). IR
(ATR): 3061, 2958, 2876, 1611, 1504, 1442, 1382, 1337, 1172, 1073, 763, 697 cm-1. MS (EI) m/z
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(relative intensity) 337 (6) [M+], 295 (100), 308 (10), 252 (6). HR-MS (EI): m/z calcd for C25H23N-H+
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336.1752, found 336.1747. The spectral data are in accordance with those reported in the literature.21
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1-n-Pentyl-3,4-diphenylisoquinoline (3ka): The representative procedure was followed using 1k
(96 mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column
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chromatography (n-hexane/EtOAc: 50/1) yielded 3ka (168 mg, 96%) as a yellow oil. H-NMR (300
MHz, CDCl3): δ = 8.31–8.19 (m, 1H), 7.71–7.63 (m, 1H), 7.61–7.53 (m, 2H), 7.42–7.28 (m, 5H), 7.27–
7.12 (m, 5H), 3.40 (t, J = 7.5 Hz, 2H), 2.07–1.89 (m, 2H), 1.66–1.37 (m, 4H), 0.96 (t, J = 7.1 Hz, 3H).
13C-NMR (75 MHz, CDCl3): δ = 161.5 (Cq), 149.3 (Cq), 141.1 (Cq), 137.7 (Cq), 136.3 (Cq), 131.4 (CH),
130.3 (CH), 129.6 (CH), 128.9 (Cq), 128.2 (CH), 127.5 (CH), 127.5 (CH), 127.1 (CH), 126.8 (CH),
126.3 (CH), 125.5 (Cq), 125.2 (CH), 35.8 (CH2), 32.2 (CH2), 29.7 (CH2), 22.6 (CH2), 14.1 (CH3). IR
(ATR): 3058, 2927, 2858, 1613, 1551, 1504, 1443, 1383, 1073, 1030, 763, 696, 612, 566 cm-1. MS (EI)
m/z (relative intensity) 351 (5) [M+], 322 (10), 308 (12), 295 (100), 252 (5), 216 (5). HR-MS (EI): m/z
calcd for C26H25N 351.1987, found 351.1998.
1,3,4-Triphenylisoquinoline (3la): The representative procedure was followed using 1l (99 mg,
0.50 mmol) and diphenylacetylene (2l) (178 mg, 1.00 mmol). Purification by column chromatography
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(n-hexane/EtOAc: 25/1) yielded 3la (147 mg, 82%) as a pale yellow solid (M.p.: 181–184 °C). H-
NMR (300 MHz, CDCl3): δ = 8.20 (dm, J = 8.5 Hz, 1H), 7.84 (dd, J = 8.0, 1.6 Hz, 2H), 7.74 (dm, J =
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8.7 Hz, 1H), 7.67–7.10 (m, 15H). C-NMR (75 MHz, CDCl3): δ = 159.9 (Cq), 149.6 (Cq), 140.9 (Cq),
139.8 (Cq), 137.5 (Cq), 136.9 (Cq), 131.3 (CH), 130.4 (CH), 130.2 (CH), 129.9 (CH), 129.7 (Cq), 128.5
(CH), 128.3 (CH), 128.3 (CH), 127.5 (CH), 127.5 (CH), 127.3 (CH), 127.0 (CH), 126.6 (CH), 126.0
(CH), 125.4 (Cq). IR (ATR): 3054, 1540, 1494, 1442, 1384, 1336, 1073, 1030, 980, 761, 700, 668, 633,
567 cm-1. MS (EI) m/z (relative intensity) 357 (50) [M+], 356 (100), 278 (11), 252 (10), 177 (5). HR-MS
(EI): m/z calcd for C27H19N 357.1517, found 357.1493. The spectral data are in accordance with those
reported in the literature.19
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1-Cyclopropyl-3,4-diphenylisoquinoline (3ma): The representative procedure was followed using 1m
(81 mg, 0.50 mmol), diphenylacetylene (2a) (178 mg, 1.00 mmol) and molecular sieves 4Å (100 mg).
Purification by column chromatography (n-hexane/EtOAc: 200/1) yielded 3ma (135 mg, 84%) as a
yellow solid (M.p.: 148–150 °C). 1H-NMR (300 MHz, CDCl3): δ = 8.50 (dd, J = 7.2, 2.0 Hz, 1H), 7.69–
7.62 (m, 1H), 7.62–7.51 (m, 2H), 7.42–7.27 (m, 5H), 7.27–7.21 (m, 2H), 7.20–7.08 (m, 3H), 2.89–2.74
(m, 1H), 1.44–1.32 (m, 2H), 1.18–1.05 (m, 2H). 13C-NMR (75 MHz, CDCl3): δ = 160.6 (Cq), 148.7
(Cq), 141.2 (Cq), 138.0 (Cq), 136.1 (Cq), 131.4 (CH), 130.4 (CH), 129.6 (CH), 128.2 (CH), 128.0 (Cq),
127.3 (CH), 127.0 (CH), 126.8 (CH), 126.3 (CH), 126.3 (Cq), 126.2 (CH), 124.8 (CH), 13.6 (CH), 9.4
(CH2). IR (ATR): 3055, 1611, 1568, 1547, 1444, 1410, 1318, 1261, 1075, 1014, 767, 694 cm-1. MS (EI)
m/z (relative intensity) 321 (68) [M+], 320 (100), 278 (5), 243 (8), 152(5), 43 (13). HR-MS (EI): m/z
calcd for C24H19N-H+ 320.1439, found 320.1438. The spectral data are in accordance with those
reported in the literature.22
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9-Methyl-2,3-diphenyl-8,9-dihydro-7H-benzo[de]quinoline (3na): The representative procedure was
followed using 1n (88 mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification
by column chromatography (n-hexane/EtOAc: 40/1) yielded 3na (157 mg, 93%) as a yellow solid
(M.p.: 145–147 °C). 1H-NMR (300 MHz, CDCl3): δ = 7.51–7.46 (m, 2H), 7.45–7.28 (m, 7H), 7.25–7.12
(m, 4H), 3.54–3.41 (m, 1H), 3.36–3.24 (m, 1H), 3.23–3.11 (m, 1H), 2.43–2.31 (m, 1H), 2.12–1.99 (m,
1H), 1.63–1.56 (d, J = 7.1, 3H). 13C-NMR (75 MHz, C2D2Cl4, 100 °C): δ = 162.0 (Cq), 148.7 (Cq),
141.3 (Cq), 138.0 (Cq), 138.0 (Cq), 136.2 (Cq), 131.2 (CH), 130.3 (CH), 129.3 (CH), 128.4 (Cq), 127.9
(CH), 127.0 (CH), 126.7 (CH), 126.4 (CH), 124.3 (CH), 123.3 (CH), 123.0 (Cq), 37.4 (CH), 30.8 (CH2),
27.8 (CH2), 19.6 (CH3). IR (ATR): 2929, 1604, 1577, 1442, 1377, 1306, 1178, 1071, 1023, 767, 699
cm-1. MS (EI) m/z (relative intensity) 335 (91) [M+], 334 (100), 320 (50), 241 (8), 43 (13). HR-MS (EI):
m/z calcd for C25H21N-H+ 334.1596, found 334.1608.
3,4-Bis(4-methoxyphenyl)-1-methylisoquinoline (3ab): The representative procedure was followed
using 1a (68 mg, 0.50 mmol) and 1,2-bis(4-methoxyphenyl)acetylene (2b) (238 mg, 1.00 mmol).
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orange solid (M.p.: 106–110 °C). H-NMR (300 MHz, CDCl3): δ = 8.20–8.11 (m, 1H), 7.73–7.62 (m,
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1H), 7.60–7.49 (m, 2H), 7.32 (d, J = 8.9 Hz, 2H), 7.13 (d, J = 8.8 Hz, 2H), 6.90 (d, J = 8.8 Hz, 2H),
6.74 (d, J = 8.9 Hz, 2H), 3.83 (s, 3H), 3.75 (s, 3H), 3.04 (s, 3H). 13C-NMR (75 MHz, CDCl3): δ = 158.6
(Cq), 158.5 (Cq), 157.3 (Cq), 149.1 (Cq), 136.4 (Cq), 133.6 (Cq), 132.4 (CH), 131.5 (CH), 129.9 (Cq),
129.7 (CH), 128.2 (Cq), 126.2 (CH), 126.1 (CH), 125.9 (Cq), 125.5 (CH), 113.7 (CH), 113.1 (CH), 55.2
(CH3), 55.1 (CH3), 22.7 (CH3). IR (ATR): 2937, 2838, 1604, 1510, 1287, 1243, 1170, 1027, 837, 814,
760, 598, 557, 530 cm-1. MS (EI) m/z (relative intensity) 355 (80) [M+], 354 (100), 340 (10), 311 (20),
296 (5), 268 (15), 239 (4), 226 (4), 43 (3). HR-MS (EI): m/z calcd for C24H21NO2 355.1572, found
355.1539. The spectral data are in accordance with those reported in the literature.23
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3,4-Bis(4-fluorophenyl)-1-methylisoquinoline (3ac): The representative procedure was followed
using 1a (68 mg, 0.50 mmol) and 1,2-bis(4-fluorophenyl)acetylene (2c) (214 mg, 1.00 mmol).
Purification by column chromatography (n-hexane/EtOAc: 8/1) yielded 3ac (116 mg, 70%) as an
orange oil. 1H-NMR (300 MHz, CDCl3): δ = 8.23–8.15 (m, 1H), 7.65–7.55 (m, 3H), 7.37–7.27 (m, 2H),
7.22–7.12 (m, 2H), 7.11–7.00 (m, 2H), 6.95–6.84 (m, 2H), 3.06 (s, 3H). 13C-NMR (126 MHz, CDCl3): δ
= 161.9 (d, 1JC–F = 247 Hz, Cq), 161.8 (d, 1JC–F = 247 Hz, Cq), 157.9 (Cq), 148.5 (Cq), 136.8 (d, 4JC–F = 3
Hz, Cq), 135.9 (Cq), 133.2 (d, 4JC–F = 4 Hz, Cq), 132.8 (d, 3JC–F = 8 Hz, CH), 131.9 (d, 3JC–F = 8 Hz, CH),
130.1 (CH), 128.0 (Cq), 126.6 (CH), 126.1 (Cq), 125.8 (CH), 125.5 (CH), 115.4 (d, 2JC–F = 21 Hz, CH),
114.6 (d, 2JC–F = 21 Hz, CH), 22.8 (CH3). 19F-NMR (282 MHz, CDCl3): δ = –114.6 (tt, J = 8.8, 5.6 Hz),
–115.2 (tt, J = 8.7, 5.5 Hz). IR (ATR): 3035, 1603, 1508, 1390, 1334, 1221, 1154, 1093, 907, 836, 759,
728, 594, 560, 547 cm-1. MS (EI) m/z (relative intensity) 331 (55) [M+], 330 (100), 315 (4), 288 (15),
268 (4). HR-MS (EI): m/z calcd for C22H15F2N 331.1173, found 331.1150.
3,4-Diethyl-1-methylisoquinoline (3ad): The representative procedure was followed using 1a (68 mg,
0.50 mmol) and 3-hexyne (2d) (82 mg, 1.00 mmol). Purification by column chromatography (n-
hexane/EtOAc: 12/1) yielded 3ad (86 mg, 86%) as a pale yellow solid (M.p.: 54–57 °C). 1H-NMR (300
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MHz, CDCl3): δ = 8.06 (ddd, J = 8.5, 1.3, 0.8 Hz, 1H), 7.96 (dt, J = 8.5, 0.8 Hz, 1H), 7.64 (ddd, J = 8.5,
6.8, 1.3 Hz, 1H), 7.48 (ddd, J = 8.5, 6.8, 1.3 Hz, 1H), 3.03 (q, J = 7.7 Hz, 2H), 2.95 (q, J = 7.7 Hz, 2H),
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2.90 (s, 3H), 1.33 (t, J = 7.7 Hz, 3H), 1.27 (t, J = 7.7 Hz, 3H). C-NMR (75 MHz, CDCl3): δ = 155.7
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(Cq), 152.5 (Cq), 135.1 (Cq), 129.4 (CH), 127.1 (Cq), 126.1 (CH), 126.0 (Cq), 125.2 (CH), 123.3 (CH),
28.5 (CH2), 22.3 (CH3), 20.6 (CH2), 15.2 (CH3), 14.9 (CH3). IR (ATR): 2963, 1614, 1566, 1451, 1391,
1311, 1054, 963, 769, 692, 616 cm-1. MS (EI) m/z (relative intensity) 199 (31) [M+], 198 (100), 184
(23), 170 (9), 128 (10), 115 (20), 77 (8), 69 (8). HR-MS (EI): m/z calcd for C14H17N 199.1361, found
199.1355. The spectral data are in accordance with those reported in the literature.19
1-Methyl-3,4-di-n-propylisoquinoline (3ae): The representative procedure was followed using 1a
(68 mg, 0.50 mmol) and 4-octyne (2e) (110 mg, 1.00 mmol). Purification by column chromatography
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(n-hexane/EtOAc: 12/1) yielded 3ae (99 mg, 87%) as a yellow oil. H-NMR (300 MHz, CDCl3): δ =
8.06 (dd, J = 8.5, 0.8 Hz, 1H), 7.94 (dd, J = 8.5, 0.8 Hz, 1H), 7.3 (ddd, J = 8.2, 6.9, 1.2 Hz, 1H), 7.47
(ddd, J = 8.2, 6.9, 1.2 Hz, 1H), 3.01–2.92 (m, 2H), 2.92–2.84 (m, 2H), 2.89 (s, 3H), 1.84–1.72 (m, 2H),
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1.71–1.58 (m, 2H), 1.07 (t, J = 6.7 Hz, 3H), 1.03 (t, J = 7.1 Hz, 3H). C-NMR (75 MHz, CDCl3): δ =
155.6 (Cq), 151.7 (Cq), 135.4 (Cq), 129.3 (CH), 126.1 (Cq), 126.1 (CH), 126.0 (Cq), 125.2 (CH), 123.5
(CH), 37.4 (CH2), 29.8 (CH2), 24.2 (CH2), 23.8 (CH2), 22.4 (CH3), 14.6 (CH3), 14.4 (CH3). IR (ATR):
2957, 2870, 1617, 1568, 1454, 1391, 1333, 1027, 754, 614 cm-1. MS (EI) m/z (relative intensity) 227
(40) [M+], 212 (80), 198 (100), 184 (50), 171 (55), 128 (23), 115 (16), 77 (6), 43 (31). HR-MS (EI): m/z
calcd for C16H21N 227.1674, found 227.1669. The spectral data are in accordance with those reported in
the literature.19
3,4-Di-n-butyl-1-methylisoquinoline (3af): The representative procedure was followed using 1a
(68 mg, 0.50 mmol) and 5-decyne (2f) (138 mg, 1.00 mmol). Purification by column chromatography
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(n-hexane/EtOAc: 12/1) yielded 3af (101 mg, 79%) as a yellow oil. H-NMR (300 MHz, CDCl3): δ =
8.05 (dd, J = 8.5, 1.0 Hz, 1H), 7.94 (dd, J = 8.5, 1.0 Hz, 1H), 7.62 (ddd, J = 7.8, 6.8, 1.1 Hz, 1H), 7.46
(ddd, J = 7.8, 6.8, 1.1 Hz, 1H), 3.04–2.86 (m, 4H), 2.90 (s, 3H), 1.79–1.65 (m, 2H), 1.65–1.40 (m, 6H),
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0.99 (t, J = 7.1 Hz, 3H), 0.97 (t, J = 7.1 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 155.5 (Cq), 151.7
(Cq), 135.3 (Cq), 129.3 (CH), 126.1 (Cq), 126.0 (CH), 126.0 (Cq), 125.1 (CH), 123.4 (CH), 35.2 (CH2),
33.1 (CH2), 32.8 (CH2), 27.4 (CH2), 23.2 (CH2), 23.0 (CH2), 22.3 (CH3), 14.1 (CH3), 13.9 (CH3). IR
(ATR): 2955, 2858, 1617, 1568, 1504, 1441, 1391, 1336, 1028, 754, 614 cm-1. MS (EI) m/z (relative
intensity) 255 (8) [M+], 240 (9), 226 (31), 213 (28), 198 (45), 184 (28), 171 (100), 128 (12), 115 (6), 43
(11). HR-MS (EI): m/z calcd for C18H25N 255.1987, found 255.1992.
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1,7-Dimethyl-3,4-diphenylisoquinoline (3oa): The representative procedure was followed using 1o
(75 mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 12/1) yielded 3oa (125 mg, 81%) as a pale orange solid (M.p.: 134–
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139 °C). H-NMR (300 MHz, CDCl3): δ = 7.96 (dq, J = 1.8, 0.9 Hz, 1H), 7.57 (d, J = 8.6 Hz, 1H),
7.45–7.30 (m, 6H), 7.26–7.14 (m, 5H), 3.06 (s, 3H), 2.57 (s, 3H). 13C-NMR (75 MHz, CDCl3): δ =
156.9 (Cq), 148.6 (Cq), 141.0 (Cq), 137.7 (Cq), 136.3 (Cq), 134.1 (Cq), 132.0 (CH), 131.3 (CH), 130.2
(CH), 129.0 (Cq), 128.1 (CH), 127.5 (CH), 127.0 (CH), 126.7 (CH), 126.2 (Cq), 126.0 (CH), 124.4
(CH), 22.7 (CH3), 21.8 (CH3). IR (ATR): 3023, 2914, 1551, 1504, 1442, 1386, 1321, 1073, 1027, 831,
767, 755, 696, 567 cm-1. MS (EI) m/z (relative intensity) 309 (65) [M+], 100 (100), 293 (8), 265 (5), 252
(15), 146 (5), 43 (6). HR-MS (ESI): m/z calcd for C23H19N+H+ 310.1590, found 310.1592. The spectral
data are in accordance with those reported in the literature.24
5,6-(Methylenedioxy)-1-methyl-3,4-diphenylisoquinoline (3pa): The representative procedure was
followed using 1p (100 mg, 0.50 mmol) and diphenylacetylene (2a) (178 mg, 1.00 mmol). Purification
by column chromatography (n-hexane/EtOAc: 10/1 → 8/1 → 6/1 → 2/1) yielded 3pa (164 mg, 86%) as
a white solid (M.p.: 251–254 °C). 1H-NMR (300 MHz, CDCl3): δ = 7.82 (d, J = 8.8 Hz, 1H), 7.37–7.06
(m, 11H), 5.83 (s, 2H), 2.99 (s, 3H). 13C-NMR (75 MHz, CDCl3): δ = 157.7 (Cq), 150.2 (Cq), 147.6 (Cq),
141.7 (Cq), 140.8 (Cq), 138.4 (Cq), 131.1 (CH), 130.2 (CH), 127.5 (CH), 127.0 (CH), 126.8 (CH), 126.7
(CH), 124.8 (Cq), 123.2 (Cq), 122.5 (Cq), 120.9 (CH), 110.8 (CH), 101.4 (CH2), 23.4 (CH3). IR (ATR):
2899, 1626, 1549, 1512, 1432, 1383, 1353, 1279, 1209, 1119, 1049, 891, 794, 760, 744, 698, 644 cm-1.
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MS (EI) m/z (relative intensity) 339 (100) [M+], 338 (98), 310 (18), 292 (14), 278 (9), 267 (6), 239 (6),
176 (5), 139 (9), 77 (7), 43 (8). HR-MS (EI): m/z calcd for C23H17NO2 339.1259, found 339.1252.
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1,4-Dimethyl-3-phenylisoquinoline (3ag): The representative procedure was followed using 1a
(68 mg, 0.50 mmol) and 1-phenyl-1-propyne (3g) (116 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 12/1) yielded 3ag (81 mg, 69%) as a red solid (M.p.: 83–87 °C). 1H-
NMR (300 MHz, CDCl3): δ = 8.15 (dd, J = 8.5, 0.9 Hz, 1H), 8.04 (dd, J = 8.5, 0.9 Hz, 1H), 7.73 (ddd,
J = 8.5, 6.8, 1.3 Hz, 1H), 7.64–7.54 (m, 3H), 7.52–7.45 (m, 2H), 7.42–7.33 (m, 1H), 2.98 (s, 3H), 2.59
(s, 3H). 13C-NMR (75 MHz, CDCl3): δ = 155.8 (Cq), 150.6 (Cq), 141.5 (Cq), 136.2 (Cq), 129.8 (CH),
129.8 (CH), 128.0 (CH), 127.4 (CH), 126.2 (CH), 126.1 (Cq), 126.0 (CH), 124.1 (CH), 122.1 (Cq), 22.5
(CH3), 15.4 (CH3). IR (ATR): 2947, 1683, 1561, 1504, 1437, 1388, 1336, 1159, 1020, 760, 699, 603,
539 cm-1. MS (EI) m/z (relative intensity) 233 (50) [M+], 232 (100), 217 (10), 202 (4), 189 (7), 128 (5),
115 (8), 77 (6), 43 (11). HR-MS (EI): m/z calcd for C17H15N 233.1204, found 233.1186. The spectral
data are in accordance with those reported in the literature.19
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4-Ethyl-1-methyl-3-phenylisoquinoline (3ah): The representative procedure was followed using 1a
(68 mg, 0.50 mmol) and 1-phenyl-1-butyne (2h) (130 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 12/1) yielded 3ah (78 mg, 63%) as a pale yellow solid (M.p.: 117–
120 °C). 1H-NMR (300 MHz, CDCl3): δ = 8.17 (ddd, J = 8.4, 1.4, 0.7 Hz, 1H), 8.07 (dd, J = 8.6, 1.0 Hz,
1H), 7.73 (ddd, J = 8.4, 6.8, 1.3 Hz, 1H), 7.59 (ddd, J = 8.1, 6.8, 1.2 Hz, 1H), 7.54–7.33 (m, 5H), 2.99
(q, J = 7.5 Hz, 2H), 2.97 (s, 3H), 1.26 (t, J = 7.5 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 155.8 (Cq),
150.7 (Cq), 141.8 (Cq), 135.1 (Cq), 129.8 (CH), 129.2 (CH), 128.5 (Cq), 128.1 (CH), 127.4 (CH), 126.7
(Cq), 126.3 (CH), 126.1 (CH), 124.1 (CH), 22.5 (CH3), 21.6 (CH2), 15.7 (CH3). IR (ATR): 2963, 1562,
1435, 1390, 1333, 1162, 1027, 861, 771, 748, 685, 620, 590 cm-1. MS (EI) m/z (relative intensity) 247
(54) [M+], 246 (100), 231 (21), 217 (10), 202 (6), 189 (5), 128 (5), 115 (7), 77 (6). HR-MS (EI): m/z
calcd for C18H17N 247.1361, found 247.1349. The spectral data are in accordance with those reported in
the literature.19
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4-n-Hexyl-1-methyl-3-phenylisoquinoline (3ai): The representative procedure was followed using 1a
(68 mg, 0.50 mmol) and 1-phenyl-1-octyne (2i) (186 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 12/1) yielded 3ai (79 mg, 52%) as an orange oil and 3ai’ (9 mg,
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6%) as an orange oil. H-NMR (300 MHz, CDCl3): δ = 8.15 (ddd, J = 8.4, 1.3, 0.8 Hz, 1H), 8.05 (dd,
J = 8.4, 0.8 Hz, 1H), 7.72 (ddd, J = 8.4, 6.8, 1.3 Hz, 1H), 7.58 (ddd, J = 8.4, 6.8, 1.3 Hz, 1H), 7.53–7.34
(m, 5H), 3.01–2.89 (m, 2H), 2.97 (s, 3H), 1.70–1.56 (m, 2H), 1.38–1.14 (m, 6H), 0.84 (t, J = 6.7 Hz,
3H). 13C-NMR (75 MHz, CDCl3): δ = 155.7 (Cq), 150.9 (Cq), 141.9 (Cq), 135.4 (Cq), 129.7 (CH), 129.3
(CH), 128.1 (CH), 127.4 (Cq), 127.3 (CH), 126.6 (Cq), 126.2 (CH), 126.1 (CH), 124.2 (CH), 31.4 (CH2),
31.2 (CH2), 29.5 (CH2), 28.5 (CH2), 22.5 (CH2), 22.5 (CH3), 14.0 (CH3). IR (ATR): 2924, 2856, 1614,
1562, 1504, 1436, 1391, 1333, 1029, 755, 698, 616, 592 cm-1. MS (EI) m/z (relative intensity) 303 (35)
[M+], 260 (10), 246 (50), 217 (15), 189 (5). HR-MS (EI): m/z calcd for C22H25N 303.1987, found
303.1982.
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3-n-Hexyl-1-methyl-4-phenylisoquinoline (3ai’): H-NMR (300 MHz, CDCl3): δ = 8.14–8.07 (m,
1H), 7.53–7.38 (m, 5H), 7.37–7.30 (m, 1H), 7.30–7.22 (m, 2H), 2.99 (s, 3H), 2.69–2.58 (m, 2H), 1.77–
1.55 (m, 2H), 1.28–1.08 (m, 6H), 0.79 (t, J = 7.0 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 157.4 (Cq),
151.7 (Cq), 137.9 (Cq), 136.0 (Cq), 130.4 (CH), 129.5 (CH), 128.9 (Cq), 128.3 (CH), 127.3 (CH), 125.8
(CH), 125.6 (CH), 125.4 (Cq), 125.3 (CH), 35.7 (CH2), 31.6 (CH2), 30.4 (CH2), 29.3 (CH2), 22.5 (CH2),
22.5 (CH3), 14.0 (CH3). IR (ATR): 2925, 2855, 1713, 1563, 1505, 1442, 1392, 1336, 1028, 758, 699,
626, 599 cm-1. MS (EI) m/z (relative intensity) 303 (4) [M+], 288 (4), 274 (5), 260 (15), 246 (20), 232
(100), 217 (10), 189 (8), 43 (7). HR-MS (EI): m/z calcd for C22H25N 303.1987, found 303.1976.
1-{4-(1,4-Dimethylisoquinolin-3-yl)phenyl}ethanone (3aj): The representative procedure was
followed using 1a (68 mg, 0.50 mmol) and 1-{4-(prop-1-yn-1-yl)phenyl}ethanone (2j) (158 mg,
1.00 mmol). Purification by column chromatography (n-hexane/EtOAc: 2/1) yielded 3aj (97 mg, 70%)
as a yellow solid (M.p.: 149–153 °C). 1H-NMR (300 MHz, CDCl3): δ = 8.17 (ddd, J = 8.3, 1.3, 0.7 Hz,
1H), 8.09–8.04 (m, 1H), 8.07 (d, J = 8.5 Hz, 2H), 7.76 (ddd, J = 8.3, 6.9, 1.3 Hz, 1H), 7.69 (d,
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J = 8.5 Hz, 2H), 7.63 (ddd, J = 8.2, 6.9, 1.2 Hz, 1H), 2.98 (s, 3H), 2.66 (s, 3H), 2.60 (s, 3H). 13C-NMR
(75 MHz, CDCl3): δ = 197.9 (Cq), 156.2 (Cq), 149.3 (Cq), 146.3 (Cq), 136.1 (Cq), 135.9 (Cq), 130.2
(CH), 130.0 (CH), 128.1 (CH), 126.7 (CH), 126.3 (Cq), 126.1 (CH), 124.1 (CH), 122.6 (Cq), 26.7 (CH3),
22.5 (CH3), 15.3 (CH3). IR (ATR): 2920, 1681, 1605, 1565, 1261, 1012, 957, 853, 834, 762, 733, 599,
540 cm-1. MS (EI) m/z (relative intensity) 275 (59) [M+], 274 (100), 231 (27), 217 (8), 188 (6), 129 (5),
115 (5), 43 (13). HR-MS (EI): m/z calcd for C19H17NO 275.1310, found 275.1299.
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4-n-Butyl-1-methyl-3-(p-tolyl)isoquinoline (3ak): The representative procedure was followed using
1a (68 mg, 0.50 mmol) and 1-(p-tolyl)-1-hexyne (2k) (172 mg, 1.00 mmol). Purification by column
chromatography (n-hexane/EtOAc: 12/1) yielded 3ak (98 mg, 68%) as an orange oil and 3ak’ (11 mg,
8%) as an orange oil. 1H-NMR (300 MHz, CDCl3): δ = 8.14 (dd, J = 8.6, 0.9 Hz, 1H), 8.04 (dt, J = 8.6,
0.9 Hz, 1H), 7.70 (ddd, J = 8.3, 6.8, 1.3 Hz, 1H), 7.56 (ddd, J = 8.3, 6.8, 1.2 Hz, 1H), 7.39 (d, J = 8.1
Hz, 2H), 7.25 (d, J = 8.1 Hz, 2H), 3.03–2.91 (m, 2H), 2.95 (s, 3H), 2.41 (s, 3H), 1.70–1.56 (m, 2H),
1.34 (dt, J = 7.3, 7.3 Hz, 2H), 0.86 (t, J = 7.3 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 155.6 (Cq),
150.9 (Cq), 139.0 (Cq), 136.9 (Cq), 135.4 (Cq), 129.6 (CH), 129.1 (CH), 128.7 (CH), 127.2 (Cq), 126.5
(Cq), 126.2 (CH), 126.0 (CH), 124.2 (CH), 33.4 (CH2), 28.3 (CH2), 23.0 (CH2), 22.5 (CH3), 21.2 (CH3),
13.8 (CH3). IR (ATR): 2955, 2923, 2869, 1614, 1563, 1513, 1438, 1391, 1333, 1026, 825, 755, 726,
615, 587, 539, 497 cm-1. MS (EI) m/z (relative intensity) 289 (50) [M+], 260 (70), 246 (100), 231 (30),
216 (8), 202 (10), 115 (5), 43 (11). HR-MS (EI): m/z calcd for C21H23N 289.1830, found 289.1833.
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3-n-Butyl-1-methyl-4-(p-tolyl)isoquinoline (3ak’): H-NMR (300 MHz, CDCl3): δ = 8.13–8.05 (m,
1H), 7.51–7.43 (m, 2H), 7.39–7.32 (m, 1H), 7.28 (d, J = 8.0 Hz, 2H), 7.14 (d, J = 8.0 Hz, 2H), 2.98 (s,
3H), 2.70–2.61 (m, 2H), 2.45 (s, 3H), 1.70–1.55 (m, 2H), 1.31–1.16 (m, 2H), 0.78 (t, J = 7.3 Hz, 3H).
13C-NMR (75 MHz, CDCl3): δ = 157.2 (Cq), 151.8 (Cq), 136.8 (Cq), 136.2 (Cq), 134.8 (Cq), 130.3 (CH),
129.4 (CH), 129.0 (CH), 128.9 (Cq), 125.9 (CH), 125.6 (CH), 125.4 (Cq), 125.3 (CH), 35.5 (CH2), 32.7
(CH2), 22.7 (CH2), 22.5 (CH3), 21.3 (CH3), 13.9 (CH3). IR (ATR): 2955, 2924, 1614, 1563, 1517, 1439,
1391, 1336, 1107, 1024, 965, 817, 758, 613 cm-1. MS (EI) m/z (relative intensity) 289 (5) [M+], 274
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for C21H23N 289.1830, found 289.1822.
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3-([1,1'-Biphenyl]-4-yl)-4-n-butyl-1-methylisoquinoline (3al): The representative procedure was
followed using 1a (68 mg, 0.50 mmol) and 1,1'-biphenyl-1-hexyne (2l) (234 mg, 1.00 mmol).
Purification by column chromatography (n-hexane/EtOAc: 12/1) yielded 3al (90 mg, 51%) as a pale
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yellow solid (M.p.: 129–130 °C). H-NMR (300 MHz, CDCl3): δ = 8.17 (d, J = 8.4 Hz, 1H), 8.07 (d,
J = 8.4 Hz, 1H), 7.78–7.55 (m, 8H), 7.51–7.43 (m, 2H), 7.41–7.33 (m, 1H), 3.10–2.96 (m, 2H), 2.99 (s,
3H), 1.76–1.60 (m, 2H), 1.38 (dt, J = 7.4, 7.4 Hz, 2H), 0.88 (t, J = 7.4 Hz, 3H). 13C-NMR (75 MHz,
CDCl3): δ = 155.9 (Cq), 150.5 (Cq), 141.1 (Cq), 140.9 (Cq), 140.1 (Cq), 135.4 (Cq), 129.7 (CH), 129.7
(CH), 128.7 (CH), 127.4 (Cq), 127.2 (CH), 127.1 (CH), 126.9 (CH), 126.6 (Cq), 126.2 (CH), 126.1
(CH), 124.2 (CH), 33.5 (CH2), 28.3 (CH2), 23.0 (CH2), 22.5 (CH3), 13.8 (CH3). IR (ATR): 2926, 2870,
1563, 1436, 1387, 1334, 1006, 927, 814, 761, 732, 692, 598, 485 cm-1. MS (EI) m/z (relative intensity)
351 (25) [M+], 322 (45), 308 (100), 231 (6), 77 (10). HR-MS (EI): m/z calcd for C26H25N 351.1987,
found 351.1979.
4-n-Butyl-1-methyl-3-(4-methoxyphenyl)isoquinoline (3am): The representative procedure was
followed using 1a (68 mg, 0.50 mmol) and 1-(4-methoxyphenyl)-1-hexyne (2m) (188 mg, 1.00 mmol).
Purification by column chromatography (n-hexane/EtOAc: 12/1) yielded 3am (87 mg, 57%) as a red
oil. 1H-NMR (300 MHz, CDCl3): δ = 8.14 (ddd, J = 8.4, 1.3, 0.7 Hz, 1H), 8.03 (dd, J = 8.6, 0.7 Hz, 1H),
7.70 (ddd, J = 8.2, 6.8, 1.3 Hz, 1H), 7.56 (ddd, J = 8.2, 6.8, 1.1 Hz, 1H), 7.44 (d, J = 8.8 Hz, 2H), 6.99
(d, J = 8.8 Hz, 2H), 3.86 (s, 3H), 3.06–2.90 (m, 2H), 2.95 (s, 3H), 1.71–1.54 (m, 2H), 1.35 (dd,
J = 7.3 Hz, 2H), 0.86 (t, J = 7.3 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 158.9 (Cq), 155.6 (Cq), 150.5
(Cq), 135.4 (Cq), 134.4 (Cq), 130.5 (CH), 129.6 (CH), 127.2 (Cq), 126.5 (Cq), 126.2 (CH), 125.9 (CH),
124.1 (CH), 113.5 (CH), 55.3 (CH3), 33.4 (CH2), 28.3 (CH2), 22.9 (CH2), 22.5 (CH3), 13.8 (CH3). IR
(ATR): 2957, 2926, 2868, 1609, 1567, 1512, 1463, 1436, 1391, 1376, 1291, 1250, 1176, 1021, 836,
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753, 615, 588, 574, 541 cm-1. MS (EI) m/z (relative intensity) 305 (72) [M+], 276 (71), 262 (100), 247
(35), 230 (6), 218 (23), 43 (8). HR-MS (EI): m/z calcd for C21H23NO 305.1780, found 305.1771.
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4-n-Butyl-3-(4-fluorophenyl)-1-methylisoquinoline (3an): The representative procedure was
followed using 1a (68 mg, 0.50 mmol) and 1-(4-fluoroyphenyl)-1-hexyne (2n) (176 mg, 1.00 mmol).
Purification by column chromatography (n-hexane/EtOAc: 12/1) yielded 3an (88 mg, 60%) as a pale
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brown solid (M.p.: 58–60 °C). H-NMR (300 MHz, CDCl3): δ = 8.15 (ddd, J = 8.4, 1.3, 0.7 Hz, 1H),
8.04 (dd, J = 8.4, 0.7 Hz, 1H), 7.72 (ddd, J = 8.4, 6.8, 1.3 Hz, 1H), 7.58 (ddd, J = 8.4, 6.8, 1.3 Hz, 1H),
7.51–7.41 (m, 2H), 7.20–7.07 (m, 2H), 3.01–2.89 (m, 2H), 2.95 (s, 3H), 1.67–1.53 (m, 2H), 1.40–1.25
(m, 2H), 0.84 (t, J = 7.3 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 162.3 (d, 1JC–F = 246 Hz, Cq), 155.9
(Cq), 149.8 (Cq), 137.9 (d, 4JC–F = 3 Hz, Cq), 135.3 (Cq), 131.0 (d, 3JC–F = 8 Hz, CH), 129.9 (CH), 127.5
(Cq), 126.7 (Cq), 126.3 (CH), 126.3 (CH), 124.2 (CH), 115.0 (d, 2JC–F = 21 Hz, CH), 33.3 (CH2), 28.2
(CH2), 22.9 (CH2), 22.5 (CH3), 13.7 (CH3). 19F-NMR (282 MHz, CDCl3): δ = –115.3 (tt, J = 8.8, 5.5
Hz). IR (ATR): 2931, 2868, 1603, 1434, 1387, 1335, 1218, 1091, 837, 761, 727, 711, 616 cm-1. MS (EI)
m/z (relative intensity) 293 (40) [M+], 264 (36), 250 (100), 235 (15), 220 (4), 207 (4), 147 (4). HR-MS
(EI): m/z calcd for C20H20FN 293.1580, found 293.1584.
Ethyl 4-(4-n-butyl-1-methylisoquinolin-3-yl)benzoate (3ao): The representative procedure was
followed using 1a (68 mg, 0.50 mmol) and ethyl 4-(hex-1-yn-1-yl)benzoate (2o) (230 mg, 1.00 mmol).
Purification by column chromatography (n-hexane/EtOAc: 12/1) yielded 3ao (81 mg, 47%) as a red oil.
1H-NMR (300 MHz, CDCl3): δ = 8.15 (dd, J = 8.6, 0.9 Hz, 1H) 8.13 (d, J = 8.1 Hz, 2H), 8.04 (dd,
J = 8.6, 0.9 Hz, 1H), 7.73 (ddd, J = 8.4, 6.9, 1.4 Hz, 1H), 7.64–7.54 (m, 3H), 4.40 (q, J = 7.1 Hz, 2H),
3.00–2.86 (m, 2H), 2.95 (s, 3H), 1.65–1.53 (m, 2H), 1.41 (t, J = 7.1 Hz, 3H), 1.30 (dt, J = 7.4, 7.4 Hz,
2H), 0.82 (t, J = 7.3 Hz, 3H). 13C-NMR (75 MHz, CDCl3): δ = 166.6 (Cq), 156.1 (Cq), 149.7 (Cq), 146.4
(Cq), 135.2 (Cq), 129.9 (CH), 129.4 (CH), 129.4 (CH), 129.3 (Cq), 127.6 (Cq), 126.8 (Cq), 126.5 (CH),
126.2 (CH), 124.2 (CH), 60.9 (CH2), 33.4 (CH2), 28.2 (CH2), 22.9 (CH2), 22.5 (CH3), 14.3 (CH3), 13.7
(CH3). IR (ATR): 2957, 2871, 1713, 1611, 1563, 1508, 1391, 1366, 1267, 1174, 1098, 1019, 866, 757,
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712, 616 cm-1. MS (EI) m/z (relative intensity) 347 (64) [M+], 318 (100), 304 (15), 290 (14), 276 (8),
260 (25), 244 (11), 231 (61), 216 (11), 202 (10), 189 (5), 115 (5), 43 (18). HR-MS (EI): m/z calcd for
C23H25NO2 347.1885, found 347.1870.
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4-(4-Hydroxy-n-butyl)-1-methyl-3-phenylisoquinoline (3ap): The representative procedure was
followed using 1a (68 mg, 0.50 mmol) and 6-phenylhex-5-yn-1-ol (2p) (174 mg, 1.00 mmol).
Purification by column chromatography (n-hexane/EtOAc: 2/1) yielded 3ap (106 mg, 73%) a pale
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brown solid (M.p.: 96–101 °C). H-NMR (300 MHz, CDCl3): δ = 8.17 (dd, J = 8.5, 1.3, 0.8 Hz, 1H),
8.06 (dd, J = 8.5, 0.8 Hz, 1H), 7.73 (ddd, J = 8.5, 6.8, 1.3 Hz, 1H), 7.59 (ddd, J = 8.1, 6.8, 1.2 Hz, 1H),
7.52–7.34 (m, 5H), 3.48 (t, J = 6.5 Hz, 2H), 3.06–2.90 (m, 2H), 2.97 (s, 3H), 1.75–45 (m, 5H).
13C-NMR (75 MHz, CDCl3): δ = 156.0 (Cq), 151.0 (Cq), 141.7 (Cq), 135.3 (Cq), 130.0 (CH), 129.3
(CH), 128.1 (CH), 127.4 (CH), 126.9 (Cq), 126.6 (Cq), 126.3 (CH), 126.2 (CH), 124.1 (CH), 62.2 (CH2),
32.5 (CH2), 29.0 (CH2), 27.2 (CH2), 22.4 (CH3). IR (ATR): 3273, 2936, 2863, 1615, 1564, 1444, 1395,
1335, 1141, 1053, 1030, 982, 759, 707, 628 cm-1. MS (EI) m/z (relative intensity) 291 (50) [M+], 246
(68), 232 (100), 217 (14), 202 (6), 189 (7), 115 (5), 77 (5), 43 (6). HR-MS (EI): m/z calcd for C20H21NO
291.1623, found 291.1623.
4-(4-Chloro-n-butyl)-1-methyl-3-phenylisoquinoline (3aq): The representative procedure was
followed using 1a (68 mg, 0.50 mmol) and 6-chloro-1-phenylhexyne (2q) (193 mg, 1.00 mmol).
Purification by column chromatography (n-hexane/EtOAc: 12/1) yielded 3aq (104 mg, 67%) as a
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yellow oil. H-NMR (300 MHz, CDCl3): δ = 8.16 (ddd, J = 8.4, 1.3, 0.8 Hz, 1H), 8.04 (dd, J = 8.4,
0.8 Hz, 1H), 7.73 (ddd, J = 8.4, 6.9, 1.3 Hz, 1H), 7.59 (ddd, J = 8.4, 6.9, 1.3 Hz, 1H), 7.53–7.34 (m,
5H), 3.42 (t, J = 6.2 Hz, 2H), 3.03–2.95 (m, 2H), 2.97 (s, 3H), 1.86–1.68 (m, 4H). 13C-NMR (75 MHz,
CDCl3): δ = 156.1 (Cq), 151.1 (Cq), 141.6 (Cq), 135.2 (Cq), 129.9 (CH), 129.2 (CH), 128.2 (CH), 127.5
(CH), 126.6 (Cq), 126.4 (Cq), 126.3 (CH), 126.2 (CH), 124.0 (CH), 44.4 (CH2), 32.3 (CH2), 28.1 (CH2),
27.5 (CH2), 22.5 (CH3). IR (ATR): 2953, 1614, 1561, 1504, 1437, 1391, 1331, 1027, 756, 699, 648,
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616, 592 cm-1. MS (EI) m/z (relative intensity) 309 (41) [M+], 246 (95), 232 (100), 217 (16), 202 (6),
189 (6), 115 (6), 77 (5). HR-MS (EI): m/z calcd for C20H20ClN 309.1284, found 309.1297.
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Competition Experiment with Alkynes 2 (Scheme 5). A mixture of acetophenone oxime (1a) (68 mg,
0.50 mmol), diphenylacetylene (2a) (356 mg, 2.00 mmol), 4-octyne (2e) (220 mg, 2.00 mmol),
[RuCl2(p-cymene)]2 (15.3 mg, 0.025 mmol, 5.0 mol %), and KPF6 (28 mg, 0.15 mmol, 30 mol %) in
MeOH (2.00 mL) was stirred at 60 °C for 24 h. At ambient temperature, EtOAc (15 mL) was added and
the solvents were removed in vacuo. Purification of the remaining residue by column chromatography
(n-hexane/EtOAc: 12/1) yielded 2aa (80 mg, 54%) as a white solid and 2ae (36 mg, 32%) as a yellow
oil.
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Competition Experiment with Oximes 1c and 1q (Scheme 6a). A mixture of oxime 1c (118 mg,
0.55 mmol), oxime 1q (91 mg, 0.55 mmol), diphenylacetylene (2a) (89 mg, 0.5 mmol), [RuCl2(p-
cymene)]2 (15.3 mg, 0.025 mmol, 5.0 mol %), and KPF6 (28 mg, 0.15 mmol, 30 mol %) in MeOH (2.00
mL) was stirred at 60 °C for 24 h. At ambient temperature, EtOAc (15 mL) was added and the solvents
were removed in vacuo. Purification of the remaining residue by column chromatography (n-
hexane/EtOAc: 12/1) yielded 3ca (8 mg, 5%) as an orange solid and 3qa (62 mg, 38%) as a pale yellow
solid (M.p.: 175–177 °C).
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6-Methoxy-1-methyl-3,4-diphenylisoquinoline (3qa): H-NMR (300 MHz, CDCl3): δ = 8.09 (d,
J = 9.1 Hz, 1H), 7.38–7.28 (m, 5H), 7.25–7.13 (m, 6H), 6.91 (d, J = 2.6 Hz, 1H), 3.71 (s, 3H), 3.01 (s,
3H). 13C-NMR (75 MHz, CDCl3): δ = 160.5 (Cq), 156.9 (Cq), 150.1 (Cq), 141.2 (Cq), 138.0 (Cq), 137.8
(Cq), 131.2 (CH), 130.2 (CH), 128.5 (Cq), 128.2 (CH), 127.5 (CH), 127.4 (CH), 127.0 (CH), 126.8
(CH), 121.8 (Cq), 118.6 (CH), 104.4 (CH), 55.2 (CH3), 22.6 (CH3). IR (ATR): 2923, 1618, 1500, 1410,
1273, 1229, 1205, 1070, 1024, 853, 823, 767, 696, 611 cm-1. MS (EI) m/z (relative intensity) 325 (55)
[M+], 324 (100), 281 (32), 239 (6), 139 (5), 43 (10). HR-MS (EI): m/z calcd for C23H19NO 325.1467,
found 325.1471. The spectral data are in accordance with those reported in the literature.19
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Competition Experiment with Oximes 1c and 1b (Scheme 6b). A mixture of oxime 1c (118 mg,
0.55 mmol), oxime 1b (82 mg, 0.55 mmol), diphenylacetylene (2a) (89 mg, 0.5 mmol), [RuCl2(p-
cymene)]2 (15.3 mg, 0.025 mmol, 5.0 mol %), and KPF6 (28 mg, 0.15 mmol, 30 mol %) in MeOH (2.00
mL) was stirred at 60 °C for 24 h. At ambient temperature, EtOAc (15 mL) was added and the solvents
were removed in vacuo. Purification of the remaining residue by column chromatography (n-
hexane/EtOAc: 12/1) yielded 3ca (13 mg, 7%) as an orange solid and 3ba (45 mg, 29%) as a pale
orange solid.
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Reaction of oxime 1a in [D4]-MeOH (Scheme 7a). A mixture of acetophenone oxime (1a) (68 mg,
0.50 mmol), [RuCl2(p-cymene)]2 (15.3 mg, 0.025 mmol, 5.0 mol %), and KPF6 (28 mg, 0.15 mmol,
30 mol %) in [D4]-MeOH (2.00 mL) was stirred at 60 °C for 24 h. At ambient temperature, EtOAc (50
mL) and H2O (20 mL) were and the organic layer was separated. The aqueous layer was extracted with
EtOAc (50 mL) and the combined organic layers were dried over Na2SO4. Evaporation of the solvents
yielded 1a (62 mg, 92%) with less than 5% deuterium incorporation in the ortho-position estimated by
1H-NMR-spectroscopy.
Reaction of substrates 1a and 2e in [D4]-MeOH (Scheme 7b). A mixture of acetophenone oxime (1a)
(68 mg, 0.50 mmol), 4-octyne (2e) (110 mg, 1.00 mmol), [RuCl2(p-cymene)]2 (15.3 mg, 0.025 mmol,
5.0 mol %), and KPF6 (28 mg, 0.15 mmol, 30 mol %) in [D]4-MeOH (2.00 mL) was stirred at 60 °C for
24 h. At ambient temperature, EtOAc (15 mL) was added and the solvents were removed in vacuo.
Purification of the remaining residue by column chromatography (n-hexane/EtOAc: 12/1) yielded 3ae
(86 mg, 76%) with 15% deuterium incorporation in the ortho-position and 57% deuterium incorporation
at the Methyl-Group as estimated by 1H-NMR-spectroscopy.
Reaction of substrates [D]5-1a and 2e (Scheme 7c). A mixture of [D]5-acetophenone oxime ([D]5-1a)
(70 mg, 0.50 mmol), 4-octyne (2e) (110 mg, 1.00 mmol), [RuCl2(p-cymene)]2 (15.3 mg, 0.025 mmol,
5.0 mol %), and KPF6 (28 mg, 0.15 mmol, 30 mol %) in MeOH (2.00 mL) was stirred at 60 °C for 24 h.
At ambient temperature, EtOAc (15 mL) was added and the solvents were removed in vacuo.
Purification of the remaining residue by column chromatography (n-hexane/EtOAc: 12/1) yielded [D]4-
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