A regio and stereospecific radical annulation route to chiral tricyclo[4.3.1.0]decane (isotwistane) system synthesis of (+)-10-α-naphthyl-5-epi-pupukean-9-one

Article abstract of DOI:10.1016/0040-4039(91)80234-W

Contrary to that of phanyl derivative 1 the radical 4 adds to radicophiles in an inter- followed by intra-molecular radical Michael addition (radical annulation), furnishing a novel route to chiral isotwistanes 5.