Tetrahedron p. 1115 - 1122 (1992)
Update date:2022-08-05
Topics:
Stoineva
Galunsky
Lozanov
Ivanov
Petkov
An enzymic synthesis of aspartame (H-Asp-Phe-OMe) has been designed and realized based on the structure-activity study of thermolysin and penicillin amidase hydrolysis of its p-substituted phenylacetyl derivatives. These compounds meet the structural and energetic requirements of two enzymic binding sites. The peptide sweetener has been prepared by thermolysin - catalyzed condensation of the p-substituted phenylacetyl-Asp-OH and H-Phe-OMe follwed by penicillin amidase - catalyzed deprotection of the resulted aspartame precursors.
View MoreContact:+86-29-88710656
Address:South Tai bai Road, High Tech Development Zone, Xi'an China
SJZ Chenghui Chemical Co., Ltd.
Contact:86-311-87713916
Address:no.368 youyi north avenue
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Pengchen New Material Technology Co., Ltd.
Contact:+86-512-63680537
Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Contact:+86-25-83719363
Address:106-7 Chunnan Rd, Chunxi Town, Gaochun, Nanjing, China
Doi:10.3987/COM-12-12508
(2012)Doi:10.1002/ejic.201200288
(2012)Doi:10.1039/c2gc35741k
(2012)Doi:10.3390/molecules25030660
(2020)Doi:10.1002/chem.201201161
(2012)Doi:10.1039/c2ob26501j
(2012)