A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge

DOI: 10.1039/c2cc34015a

Source and publish data:

Chemical Communications p. 11014 - 11016 (2012)

Update date:2022-07-29

Topics:

Authors:

Seidu-Larry, Salifu

Krieg, Bettina

Hirsch, Markus

Helm, Mark

Domingo, Olwen

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Article abstract of DOI:10.1039/c2cc34015a

A propargyl containing guanosine phosphoramidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activity.

Full text of DOI:10.1039/c2cc34015a

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