Journal of Medicinal Chemistry p. 1799 - 1806 (1992)
Update date:2022-09-26
Topics:
Slusarchyk, William A.
Bisacchi, Gregory S.
Field, A. Kirk
Hockstein, Deborah R.
Jacobs, Glenn A.
et al.
A series of racemic (1α(E),2β,3α)-1-<2,3-bis(hydroxymethyl)cyclobutyl>-5-(2-halovinyl)uracils was synthesized and evaluated in cell culture.The bromovinyl, iodovinyl, and chlorovinyl analogues, 13, 15, and 16, respectively, are all potent inhibitors of va
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