Synthesis and Antiviral Activity of 1-Cyclobutyl-5-(2-bromovinyl)uracil Nucleoside Analogues and Related Compounds

DOI: 10.1021/jm00088a015

Source and publish data:

Journal of Medicinal Chemistry p. 1799 - 1806 (1992)

Update date:2022-09-26

Topics:

Authors:

Slusarchyk, William A.

Bisacchi, Gregory S.

Field, A. Kirk

Hockstein, Deborah R.

Jacobs, Glenn A.

et al. et al.

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Article abstract of DOI:10.1021/jm00088a015

A series of racemic (1α(E),2β,3α)-1-<2,3-bis(hydroxymethyl)cyclobutyl>-5-(2-halovinyl)uracils was synthesized and evaluated in cell culture.The bromovinyl, iodovinyl, and chlorovinyl analogues, 13, 15, and 16, respectively, are all potent inhibitors of va

Full text of DOI:10.1021/jm00088a015

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