A novel class of platelet activating factor (PAF) antagonists. I. Synthesis and structure-activity studies on PAF-sulfonamide isosteres

DOI: 10.1248/cpb.40.75

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 75 - 84 (1992)

Update date:2022-08-05

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Authors:

Tsuri Tsuri

Haga Haga

Matsui Matsui

Kamata Kamata

Kakushi Kakushi

Uchida Uchida

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Article abstract of DOI:10.1248/cpb.40.75

New platelet activating factor (PAF) antagonists, 3 were synthesized by replacing the charged phosphate and trimethylammonium moieties with sulfonamide and heterocyclic quarternary ammonium functionalities, respectively (PAF-sulfonamide isosteres). Darmst

Full text of DOI:10.1248/cpb.40.75

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