Chinese Chemical Letters p. 1141 - 1144,4 (2012)
Update date:2022-08-04
Topics:
Ling, Yong
Chen, Guang Tong
Wang, Dong Geng
Li, Yu Qin
Wang, Xin Yang
Xiao, You An
Zheng, Heng
Novel farnesylthiosalicylic acid (FTA) derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5c, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.
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