Preparation of an angiotensin i analog containing a p-phosphonomethyl-l-phenylalanine residue via asymmetric synthesis of t-boc-p-dimethylphosphonomethyl-l-phenylalanine

Article abstract of DOI:10.1016/S0040-4039(00)91893-8

t-BOC-p-Dimethylphoshonomethyl-L-phenylalanine has been prepared and incorporated into a peptide sequence corresponding to angiotensin I. Demethylation of the dimethylphosphonomethyl moiety then yielded a peptide containing a p-phosphonomethyl-L-phenylalanine residue.