Chemical and Pharmaceutical Bulletin p. 1287 - 1292 (1997)
Update date:2022-07-29
Topics:
Cuberes, Maria Rosa
Contijoch, Montserrat
Calvet, Carme
Alegre, Julia
Quintana, Jordi Ramon
Frigola, Jordi
New 2-(4-(4-azolylbutyl)piperazinyl)-, 2-(4-(4- azolylbutyl)piperazinylmethyl)- 2-(4-(4-azolylbutyl)homopiperazinyl)- and 2- (4-(4-azolylbutyl)homopiperazinylmethyl)benzimidazoles were synthesized characterized and tested for in vitro and in vivo H1-antihistaminic activity. Structure-activity relationships implied that the best anti histaminic activity required the simultaneous presence of a homopiperazinylbenzimidazole system (or a methylene linker between the benzimidazole and the piperazine rings) and an unsubstituted pyrazole ring. 1-(2-Ethoxyethyl)-2-{4-[4-(pyrazol-1-yl)batyl]homopiperazin-1- yl}benzimidazole (17), as its dimaleate salt, has been chosen for further development.
View MoreShuanghe Bio-Technology Limited(expird)
Contact:+86-571-61710758,18968016640
Address:Jinqiao north road 916# Fuyang
TIANJIN GST CHEMICAL TECHNOLOGY CO., LTD
Contact:+86-22-25210964
Address:Room. 208, No. -12-C, No. 13, Xinbei Road, Tanggu District, New Haixin Area, Tianjin City, China
Contact:0572-2722882
Address:1201,F3,xinghuibandao,
Anhui Sholon New Material Technology Co., Ltd.
website:http://www.sholonchem.com
Contact:+86-550-5261666
Address:4/F Block B, Beijing Chemical Building.No.520 Tianrun Road ,Science & Education Town Wujin District, Changzhou City Jiangsu Province
Contact:13736652831
Address:NO.273 SHANGHAI SOUTH STREET,LUQIAO DISTRICT,ZHEJIANG PROVINCE,CHINA.
Doi:10.1002/ejoc.201402732
(2014)Doi:10.1016/S0040-4039(00)91734-9
(1992)Doi:10.1021/ol3028412
(2012)Doi:10.1021/acs.oprd.0c00428
(2021)Doi:10.1016/0008-6215(83)88038-0
(1983)Doi:10.1021/jo00112a048
(1995)
