Chemical and Pharmaceutical Bulletin p. 1287 - 1292 (1997)
Update date:2022-07-29
Topics:
Cuberes, Maria Rosa
Contijoch, Montserrat
Calvet, Carme
Alegre, Julia
Quintana, Jordi Ramon
Frigola, Jordi
New 2-(4-(4-azolylbutyl)piperazinyl)-, 2-(4-(4- azolylbutyl)piperazinylmethyl)- 2-(4-(4-azolylbutyl)homopiperazinyl)- and 2- (4-(4-azolylbutyl)homopiperazinylmethyl)benzimidazoles were synthesized characterized and tested for in vitro and in vivo H1-antihistaminic activity. Structure-activity relationships implied that the best anti histaminic activity required the simultaneous presence of a homopiperazinylbenzimidazole system (or a methylene linker between the benzimidazole and the piperazine rings) and an unsubstituted pyrazole ring. 1-(2-Ethoxyethyl)-2-{4-[4-(pyrazol-1-yl)batyl]homopiperazin-1- yl}benzimidazole (17), as its dimaleate salt, has been chosen for further development.
View MoreContact:+86-710-3516804
Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Contact:0510-85393305
Address:1619 Huishan Avenue, Huishan District, Wuxi,
Chengdu Baishixing Science and Technology Industry Co., Ltd.
website:http://www.cd-bsx.com
Contact:+86-28-88531548
Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
Ji'an Hairui Natural Plant Co. Ltd.
Contact:0796-8105528
Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Changzhou LanXu Chemical Co.,ltd.(expird)
Contact:86-0519-86330911,13656129734,15261186386
Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
Doi:10.1002/ejoc.201402732
(2014)Doi:10.1016/S0040-4039(00)91734-9
(1992)Doi:10.1021/ol3028412
(2012)Doi:10.1021/acs.oprd.0c00428
(2021)Doi:10.1016/0008-6215(83)88038-0
(1983)Doi:10.1021/jo00112a048
(1995)
