A highly stereoselective synthesis of axially chiral biaryls. Application to the synthesis of a potential chiral catalyst

Article abstract of DOI:10.1016/S0040-4039(00)91558-2

Excellent diastereoselectivities (>98.2) have been obtained in the biaryl coupling of 2',6',-disubstituted aryl Grignard reagents 1 with aryl oxazolines 6, conveniently synthesised from the optically pure amino alcohols L-valinol and (S)-t-leucinol.