Enantioselective Synthesis of α-Amino Phosphonic Acids by an Application of Stereoselective Opening of Homochiral Dioxane Acetals with Triethyl Phosphite

Article abstract of DOI:10.1016/S0957-4166(00)80280-3

Stereoselective opening of homochiral acetals (2a-c) with triethyl phosphite was applied to the enantioselective synthesis of phosphono alcohols (1a-c), which were succssefully converted to the α-amino phosphonic acid diethyl esters (6a-c).