Diastereoselective Addition of Organometallics to α-Keto Esters Bearing chiro-Inositol Derivatives as Chiral Auxiliaries

DOI: 10.1246/cl.1992.447

Source and publish data:

Chemistry Letters p. 447 - 450 (1992)

Update date:2022-08-05

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Authors:

Akiyama, Takahiko

Nishimoto, Hiroyuki

Ishikawa, Keiichiro

Ozaki, Shoichiro

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Article abstract of DOI:10.1246/cl.1992.447

The nucleophilic addition of organometallics to α-keto esters derived from (1L)-1,2:5,6-di-O-cyclohexylidene-3-t-butyldimethylsilyl-chiro-inositol afforded the corresponding α-hydroxy esters of high diastereomeric excess (up to 98percent de).Grignard reag

Full text of DOI:10.1246/cl.1992.447

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