Diastereoselective Addition of Organometallics to α-Keto Esters Bearing chiro-Inositol Derivatives as Chiral Auxiliaries

Article abstract of DOI:10.1246/cl.1992.447

The nucleophilic addition of organometallics to α-keto esters derived from (1L)-1,2:5,6-di-O-cyclohexylidene-3-t-butyldimethylsilyl-chiro-inositol afforded the corresponding α-hydroxy esters of high diastereomeric excess (up to 98percent de).Grignard reag