Synthesis and human immunodeficiency virus (HIV-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety

DOI: 10.1248/cpb.42.2636

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2636 - 2640 (1994)

Update date:2022-08-04

Topics:

Authors:

Kitazaki

Asano Asano

Kato Kato

Kishimoto

Itoh Itoh

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.2636

Tripeptide analogues 2 and 3 containing a dioxoethylene moiety were designed based on the characteristic structure of the naturally occurring human immunodeficiency virus (HIV)-I protease inhibitors RPI-856 A, B, C and D (1). The compounds (2, 3) prepared showed high inhibitory activity, comparable to that of RPI-856 A, against HIV-1 protease in vitro.

Full text of DOI:10.1248/cpb.42.2636

NII-Electronic Library Service

Products guided by the article

Product name:L-Prolinamide,N2-(2-quinolinylcarbonyl)-L-asparaginyl-(aS,bS)-b-amino-a-hydroxybenzenebutanoyl-N-(1,1-dimethylethyl)-(9CI)

Cas No:141171-80-4

R&D Labs maybe for 141171-80-4

Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China
Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Xiamen XM-Innovation Chemical Co., Ltd

Contact:+86-592-3216205

Address:Unit Q, 11/F, No.1 Office Building, Wuyuan Bay Business Center, Huli District, Xiamen City, Fujian Province, P.R.C
Lonzeal Pharmaceuticals Co., Ltd.

website:http://www.lonzeal.com

Contact:+86-13381011962

Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
CHINA MEHECO CORPORATION

Contact:+86-10-67147360/67107388

Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China

Relevant to this article

Acylated 2,2-dimethylaziridines: Regioselectivity of ring opening by sodium thiophenolate; borderline S(N)2 due to planarization of nitrogen pyramid

Doi:10.1016/S0040-4020(01)88757-3
(1992)
Basic Character of Rare Earth Metal Alkoxides. Utilization in Catalytic C-C Bond-Forming Reactions and Catalytic Asymmetric Nitroaldol Reactions

Doi:10.1021/ja00037a068
(1992)
Peptide peak intensities enhanced by cysteine modifiers and MALDI TOF MS

Doi:10.1002/jms.3093
(2012)
Rh-catalyzed enantioselective hydrogenation of vinyl boronates for the construction of secondary boronic esters

Doi:10.1021/ol060735u
(2006)
Novel skeleton transformation reaction of α-pyrone derivatives to spirobicyclo[3.1.0]hexane derivatives using dimethylsulfoxonium methylide

Doi:10.1021/ol302942m
(2012)
Reactions of nitroxides XIII: Synthesis of the Morita-Baylis-Hillman adducts bearing a nitroxyl moiety using 4-acryloyloxy-2,2,6,6- tetramethylpiperidine-1-oxyl as a starting compound, and DABCO and quinuclidine as catalysts

Doi:10.3762/bjoc.8.171
(2012)

Article Doi