Synthesis and human immunodeficiency virus (HIV-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety

DOI: 10.1248/cpb.42.2636

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2636 - 2640 (1994)

Update date:2022-08-04

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Authors:

Kitazaki

Asano Asano

Kato Kato

Kishimoto

Itoh Itoh

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Article abstract of DOI:10.1248/cpb.42.2636

Tripeptide analogues 2 and 3 containing a dioxoethylene moiety were designed based on the characteristic structure of the naturally occurring human immunodeficiency virus (HIV)-I protease inhibitors RPI-856 A, B, C and D (1). The compounds (2, 3) prepared showed high inhibitory activity, comparable to that of RPI-856 A, against HIV-1 protease in vitro.

Full text of DOI:10.1248/cpb.42.2636

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