SERINE DERIVED OXAZOLIDINES AS SECONDARY STRUCTURE DISRUPTING, SOLUBILIZING BUILDING BLOCKS IN PEPTIDE SYNTHESIS

DOI: 10.1016/S0040-4039(00)91681-2

Source and publish data:

Tetrahedron Letters p. 1589 - 1592 (1992)

Update date:2022-08-04

Topics:

Authors:

Haack, Thomas

Mutter, Manfred

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Article abstract of DOI:10.1016/S0040-4039(00)91681-2

The incorporation of serine as oxazolidine protected "pseudo proline" in a host peptide results in the disruption of secondary structure formation thus increasing the solvation of the peptide chain.The use of this protection technique for serine, threonine or cysteine represents a powerful tool to modulate the conformational and physico-chemical properties of peptides.

Full text of DOI:10.1016/S0040-4039(00)91681-2

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