Formamidines in Synthesis. An Efficient One-Pot Synthesis of 7-Substituted Indolines via Intramolecular Cyclization of (2-Phenethyl)formamidines. An Asymmetric Route to Benzopyrrocoline Alkaloids.

Article abstract of DOI:10.1021/jo00039a029

o-Chloro-β-phenethylamines, transformed into the N-tert-butylformamidines, were found to be excellent precursors to indolines following benzyne formation.A series of methoxy-substituted o-chlorophenethylamines containing an N-alkyl or aryl substituent wer