L-aspartic acid bis(trimethylsilyl) ester: A convenient starting material for the acylation of L-aspartic acid

DOI: 10.1016/0040-4020(92)85013-5

Source and publish data:

Tetrahedron p. 3377 - 3384 (1992)

Update date:2022-09-26

Topics:

Authors:

Castano, Ana M.

Echavarren, Antonio M.

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Article abstract of DOI:10.1016/0040-4020(92)85013-5

Reaction of L-aspartic acid with excess of bis(trimethylsilyl)amine under reflux provides optically pure L-aspartic acid bis(trimethylsilyl) ester in quantitative yield. This silyl ester reacts with a variety of acylating reagens in tetrahydrofuran to give N-protected aspartic acids and dipeptides in good yields without racemization.

Full text of DOI:10.1016/0040-4020(92)85013-5

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