A Novel Stereospecific Rearrangement of 3-Substituted B-Homo 5-Azasteroids to Their A-Nor Analogues. Preparation, Stereochemistry, and Conformational Studies

Article abstract of DOI:10.1021/jo00041a013

The novel 3α- and 3β-hydroxy-B-homo-5-azasteroid lactams 4 and 5 were prepared from testosterone.When the hydroxyl group in these compounds is converted into a leaving group, rearrangement to the corresponding A-nor azasteroids occurs under a variety of c