Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities

DOI: 10.1021/jm00093a003

Source and publish data:

Journal of Medicinal Chemistry p. 2728 - 2735 (1992)

Update date:2022-08-05

Topics:

Authors:

Mullah Mullah

Rao Rao

Balzarini

De Clercq

Bentrude

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00093a003

The preparations and antiviral activities of a series (4-17) of potential prodrug forms of the antivirals 2',3'-didehydro-2',3'-dideoxyadenosine (D4A) and 2',3'-didehydro-2',3'-dideoxycytosine (D4C) are reported. The 5'-phenyl and 5'-methylphosphonates (4

Full text of DOI:10.1021/jm00093a003

Products guided by the article

Product name:Benzoic acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Cas No:142068-19-7

R&D Labs maybe for 142068-19-7

Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd

Contact:0086-10-64430626

Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Zhangjiagang Jianing Import & Export Co.,Ltd.

Contact:086-512-55379012 13913607595

Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
MENGNA

Contact:18698110882

Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
HEZE KINGVOLT CHEMICAL CO., LTD

Contact:86-573-82118911

Address:Juancheng Industry Park
HEZE KINGVOLT CHEMICAL CO., LTD

Contact:86-573-82118911

Address:Juancheng Industry Park

Relevant to this article

Relative stereochemical determination and synthesis of the C17-C25 δ-lactone fragment of hemicalide

Doi:10.1021/jo302440a
(2013)
5-(3,4-dichlorophenyl)-3-{[4-(2-pyridyl)piperazine-1-yl]methyl}-1,3, 4-oxadiazole-2(3H)-one: Synthesis, characterization, X-ray and DFT structures

Doi:10.1134/S0022476612050162
(2012)
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor

Doi:10.1021/jm500973a
(2014)
Design, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analogues

Doi:10.3390/molecules171214126
(2012)
Design, synthesis, characterization and in vitro and in vivo anti-inflammatory evaluation of novel pyrazole-based chalcones

Doi:10.3109/14756366.2013.873037
(2015)
Antirheumatic agents. I. Novel methotrexate derivatives bearing an indoline moiety

Doi:10.1248/cpb.44.1332
(1996)

Article Doi