A Difference CD Method for Determining Absolute Stereochemistry of Acyclic 1,2,4-Triols

Article abstract of DOI:10.1016/0040-4020(95)00329-7

A general method based on difference circular dichroic (DIF CD) spectroscopy for assigning the absolute configuration of 1,2,4-triol is presented.Four possible stereoisomers of 6-heptene-1,2,4-triol were prepared and served as models to develop the procedure.The sign of the DIF CD Cotton effect is correlated to the absolute configuration of the C2 position.