Chemical Communications p. 13008 - 13011 (2019)
Update date:2022-08-03
Topics:
Zhao, Jingnan
Yang, Fan
Yu, Zongyi
Tang, Xiaofei
Wu, Yufeng
Ma, Cunfei
Meng, Qingwei
A visible light-mediated α-functionalization of 1,3-dicarbonyl compounds with switchable selectivity induced by disulfide is disclosed. Upon irradiation with visible light, the metal- A nd base-free α-hydroxylation or α-hydroxymethylation reaction proceeded smoothly through a disulfide-catalyzed oxidation under mild conditions. The combination of a continuous-flow strategy could further improve the reaction efficiencies.
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Doi:10.1021/jm00342a043
(1963)Doi:10.1055/s-0032-1317859
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