72. Synthesis of 2-Substituted and 2,3-Disubstituted Alkyl-and Aryl-thiophenes and Related 2,3-Anellated Thiophene Derivatives, Using Ketones and Carbonodithioic Acid O-Ethyl S-(2-Oxoethyl) Ester as the Building Blocks

Article abstract of DOI:10.1002/hlca.19920750325

A simple method to synthesize 2-substituted and 2,3-disubstituted alkyl- and aryl-thiophenes as well as related 2,3-anellated thiophenes 6, starting from ketones 1 as C2-fragment and the S-protected carbonodithionic-acid derivative 3 as a C2S-fragment is described.The aldols 4 are intermediates of the two step process.