Bulletin of the Chemical Society of Japan p. 2700 - 2706 (1993)
Update date:2022-09-26
Topics:
Hojo, Hironobu
Kwon, Yeondae
Kakuta, Yoshimitsu
Tsuda, Sakae
Tanaka, Isao
et al.
An S-alkyl-thioester-moiety-containing linker with an enhanced stability on a resin has been developed.A linker containing S-alkyl thioester with a spacer group, -CO-SC(CH3)2CH2CO-Nle-, was stable during the peptide chain elongation cycle.This thioester was stable under HF treatment conditions, and was rapidly activated by silver ions in the presence of N-hydroxysuccinimde (HONSu) to form a peptide bond.Using this linker, peptide segments covering the HU-type DNA-binding protein of Bacillus stearothermophilus (HBs), which was site-specifically labelled with 2H, 13C,and 15N, were prepared.Using these peptide segments, multi-labelled HBs was synthesized.Distinct signals of 2H, 13C, and 15N in HBs were detected by NMR spectrometry.
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