The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C1-Modified Analogues

DOI: 10.1021/jm00046a011

Source and publish data:

Journal of Medicinal Chemistry p. 3274 - 3281 (1994)

Update date:2022-07-30

Topics:

Authors:

Procopiou, Panayiotis A.

Bailey, Esme J.

Bamford, Mark J.

Craven, Andy P.

Dymock, Brian W.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00046a011

Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene synthase (SQS) in vitro.While maintaining the 4,6-dimethyloctenoate or 4,6-dimethyloctanoate ester grou

Full text of DOI:10.1021/jm00046a011

Products guided by the article

Product name:squalestatin 2

Cas No:142505-91-7

R&D Labs maybe for 142505-91-7

Linyi Shengxin Pharmaceutical R&D Co., Ltd

Contact:+86-18653953873

Address:West First of Yufeng Road, Yishui County
Chemsky（shanghai）International Co.,Ltd.

Contact:0

Address:0
Greenspring Biotechnology (Jiangsu) Co.,Ltd.

website:http://www.sunmy.com

Contact:+86-523-87726088

Address:Room 203, building 19, Talent Technology Plaza, Chengdong High Tech Zone, Taixing City, Jiangsu Province, China
Zhejiang Sucon Silicone Co.,Ltd

Contact:+86-575-88046692

Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED

Contact:+86-0532-82683616

Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China

Relevant to this article

On the Unusual Propensity by the Red Seaweed Laurencia microcladia of Il Rogiolo to Form C15 Oxepanes: Isolation of Rogioloxepane A, B, C, and Their Likely Biogenetic Acyclic Precursor, Prerogioloxepane

Doi:10.1002/hlca.19920750128
(1992)
An efficient titanium amidinate catalyzed version of Ziegler's "aufbaureaktion"

Doi:10.1002/ejic.201201194
(2013)
Asymmetric Synthesis of β-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

Doi:10.1021/jo00088a034
(1994)
Conformational analysis of substituted hexahydropyrrolo [2,3-b]indoles and related systems. An unusual example of hindered rotation about sulfonamide S-N bonds. An X-ray crystallographic and NMR study

Doi:10.1016/0040-4020(95)00001-O
(1995)
A Silver-Catalyzed Modular Intermolecular Access to 6,6-Spiroketals

Doi:10.1002/adsc.201900988
(2019)
Hydrogen phosphates: Self initiated organocatalysts for the controlled ring-opening polymerization of cyclic esters

Doi:10.1016/j.ica.2013.02.006
(2013)

Article Doi