The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C1-Modified Analogues

DOI: 10.1021/jm00046a011

Source and publish data:

Journal of Medicinal Chemistry p. 3274 - 3281 (1994)

Update date:2022-07-30

Topics:

Authors:

Procopiou, Panayiotis A.

Bailey, Esme J.

Bamford, Mark J.

Craven, Andy P.

Dymock, Brian W.

et al. et al.

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Article abstract of DOI:10.1021/jm00046a011

Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene synthase (SQS) in vitro.While maintaining the 4,6-dimethyloctenoate or 4,6-dimethyloctanoate ester grou

Full text of DOI:10.1021/jm00046a011

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