The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C1-Modified Analogues

DOI: 10.1021/jm00046a011

Source and publish data:

Journal of Medicinal Chemistry p. 3274 - 3281 (1994)

Update date:2022-07-30

Topics:

Authors:

Procopiou, Panayiotis A.

Bailey, Esme J.

Bamford, Mark J.

Craven, Andy P.

Dymock, Brian W.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00046a011

Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene synthase (SQS) in vitro.While maintaining the 4,6-dimethyloctenoate or 4,6-dimethyloctanoate ester grou

Full text of DOI:10.1021/jm00046a011

Products guided by the article

Product name:squalestatin 2

Cas No:142505-91-7

R&D Labs maybe for 142505-91-7

Cartoon Ingredients Co., Ltd

website:http://www.cartoonchem.com/

Contact:+86-25-58074918

Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
LIAOYANG WANRONG CHEMICALS COMPANY LIMITED

Contact:86-419-2390789

Address:XINLI VILLAGE , DONG NINGWEI COUNTY,TAIZIHE DISTRICT, LIAOYANG , LIAONING
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.

Contact:+86-21-51320130-801, 816

Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Shandong Yubin Chemical CO.,LTD

website:http://www.yukaichem.com/en.html

Contact:+86-536-8865336

Address:binhai economic development zone，262737 shangdong，china
Zhengzhou Xinlian Chemical Tech Co. ,Ltd

Contact:0371-65771781 021-52042910

Address:H Part, Building I, No. 700 Gonglu Road, Pudong New Area, Shanghai

Relevant to this article

On the Unusual Propensity by the Red Seaweed Laurencia microcladia of Il Rogiolo to Form C15 Oxepanes: Isolation of Rogioloxepane A, B, C, and Their Likely Biogenetic Acyclic Precursor, Prerogioloxepane

Doi:10.1002/hlca.19920750128
(1992)
An efficient titanium amidinate catalyzed version of Ziegler's "aufbaureaktion"

Doi:10.1002/ejic.201201194
(2013)
Asymmetric Synthesis of β-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

Doi:10.1021/jo00088a034
(1994)
Conformational analysis of substituted hexahydropyrrolo [2,3-b]indoles and related systems. An unusual example of hindered rotation about sulfonamide S-N bonds. An X-ray crystallographic and NMR study

Doi:10.1016/0040-4020(95)00001-O
(1995)
A Silver-Catalyzed Modular Intermolecular Access to 6,6-Spiroketals

Doi:10.1002/adsc.201900988
(2019)
Hydrogen phosphates: Self initiated organocatalysts for the controlled ring-opening polymerization of cyclic esters

Doi:10.1016/j.ica.2013.02.006
(2013)

Article Doi