The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C1-Modified Analogues

DOI: 10.1021/jm00046a011

Source and publish data:

Journal of Medicinal Chemistry p. 3274 - 3281 (1994)

Update date:2022-07-30

Topics:

Authors:

Procopiou, Panayiotis A.

Bailey, Esme J.

Bamford, Mark J.

Craven, Andy P.

Dymock, Brian W.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00046a011

Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene synthase (SQS) in vitro.While maintaining the 4,6-dimethyloctenoate or 4,6-dimethyloctanoate ester grou

Full text of DOI:10.1021/jm00046a011

Products guided by the article

Product name:squalestatin 2

Cas No:142505-91-7

R&D Labs maybe for 142505-91-7

Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
Linyi VIHO Chemical Co.,Ltd

Contact:86-15588110016

Address:LINYI CITY,SHANDONG PROVINCE,CHINA
Penglai Qianwei Chemical Co., Ltd.

Contact:86-535-3357802

Address:Shahelu (north), Penglai, Shandong, China
Chiral Quest (Suzhou) Company Ltd

website:http://www.chiralquest.com

Contact:+86-0512-62956066

Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park
Changyi Xinxing Technology Development Co., Ltd.

Contact:0086-510-86651065(Time Zone:8),86651656

Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China

Relevant to this article

On the Unusual Propensity by the Red Seaweed Laurencia microcladia of Il Rogiolo to Form C15 Oxepanes: Isolation of Rogioloxepane A, B, C, and Their Likely Biogenetic Acyclic Precursor, Prerogioloxepane

Doi:10.1002/hlca.19920750128
(1992)
An efficient titanium amidinate catalyzed version of Ziegler's "aufbaureaktion"

Doi:10.1002/ejic.201201194
(2013)
Asymmetric Synthesis of β-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

Doi:10.1021/jo00088a034
(1994)
Conformational analysis of substituted hexahydropyrrolo [2,3-b]indoles and related systems. An unusual example of hindered rotation about sulfonamide S-N bonds. An X-ray crystallographic and NMR study

Doi:10.1016/0040-4020(95)00001-O
(1995)
A Silver-Catalyzed Modular Intermolecular Access to 6,6-Spiroketals

Doi:10.1002/adsc.201900988
(2019)
Hydrogen phosphates: Self initiated organocatalysts for the controlled ring-opening polymerization of cyclic esters

Doi:10.1016/j.ica.2013.02.006
(2013)

Article Doi