Trimanganese complexes bearing bidentate nitrogen ligands as a highly efficient catalyst precursor in the epoxidation of alkenes

Article abstract of DOI:10.1021/jo060709+

A series of trinuclear manganese complexes coordinated with neutral bidentate nitrogen ligands, [Mn₃L₂-(OAc)₆], were prepared from manganese acetate and the corresponding ligands. Using peracetic acid as the oxidant, the air- and moisture-stable manganese clusters exhibited excellent catalytic activity and selectivity in the epoxidation of olefins under mild conditions. The highest activity was observed with a trinuclear complex containing a 2-pyridylimino ligand, [Mn₃(ppei) ₂(OAc)₆] (ppei = 2-pyridinal-1-phenylethylimine). With this system, the substrate scope was extremely wide to include terminal and electron-deficient double bonds of both aliphatic and aromatic alkenes. The high activity was undiminished under the reaction conditions even directly using a mixture of the pyridylimino ligands and manganese acetates, making this process more convenient. It was also observed that analogous trinuclear complexes, such as [Mn₃(bipy)₂(OAc)₆] and [Mn ₃(phen)₂(OAc)₆], displayed excellent activities. While radical intermediacy was inferred from the product distribution, kinetic data revealed that the epoxidation is roughly first-order in manganese cluster precursor and oxidant, respectively, and zero-order in olefin. These results led us to propose that the trinuclear complexes [Mn ₃L₂(OAc)₆] serve as catalyst precursors that dissociate into monomeric species with the formulation of [MnL ₂(OAc)₂] under the reaction conditions.