Synthesis of berberine bromide analogs containing tertiary amides of acetic acid in the 9-O-position

Article abstract of DOI:10.1007/s10600-013-0461-z

9-O-Acetamide analogs of berberine bromide were prepared in 20-87% yields via reaction of the isoquinoline alkaloid berberrubine with tertiary amides of bromoacetic acid. Aminolysis did not occur during reaction of methyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetate with secondary amines. The corresponding acid or its ethyl ester was isolated.