Dipeptide Isosteres. 2. Synthesis of Hydroxyethylene Dipeptide Isostere Diastereomers From a Common γ-Lactone Intermediate. Preparation of Renin and HIV-1 Protease Inhibitor Transition State Mimics.

Article abstract of DOI:10.1016/S0040-4020(01)81896-2

A general strategy for the synthesis of the hydroxyethylene dipeptide isostere diastereomers C or D has been developed.The syntheses proceeded through a common γ-lactone intermediate A or B.The C(3α)γ-lactone diastereomer A was prepared from the N-Cbz pro