Asymmetric synthesis and biological activities of natural product (+)-balasubramide and its derivatives

Article abstract of DOI:10.1080/14786419.2015.1071363

The natural product (+)-balasubramide (3j) and its derivatives (3a-3i) were synthesized using a two-step asymmetric synthesis, and the biological activities of 3a-3j were determined in vitro. Methyl (2S,3R)-(+)-3-phenyloxirane-2-carboxylate (1h), the asym