Synthesis of a Cyclic Peptide Polyamine: A Comparative Study of Routes to Cyclo-(Lys-Lys-Gly)2

DOI: 10.1016/S0040-4039(00)79853-4

Source and publish data:

Tetrahedron Letters p. 3207 - 3210 (1992)

Update date:2022-08-04

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Authors:

Bailey, Patrick D.

Crofts, Gavin A.

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Article abstract of DOI:10.1016/S0040-4039(00)79853-4

Several methods for the preparation of cyclo-(Lys-Lys-Gly)2 were compared.Cyclisation of linear hexapeptides of the type H-2-X was most efficient using excess DPPA with the free amino acid (i.e.X = OH), but purification and scale-up wer

Full text of DOI:10.1016/S0040-4039(00)79853-4

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