Synthetic Studies towards Halichondramides, and Related Novel tris-Oxazole Containing Macrolides from Marine Organisms. A Concise Route to the Keto-triol Formyl Enamine Moiety.

DOI: 10.1016/S0040-4039(00)79858-3

Source and publish data:

Tetrahedron Letters p. 3227 - 3230 (1992)

Update date:2022-08-05

Topics: Synthetic studies Marine Organisms Concise Route

Authors:

Kiefel, Milton J.

Maddock, John

Pattenden, Gerald

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Article abstract of DOI:10.1016/S0040-4039(00)79858-3

A synthesis of the keto-triol formyl enamine moiety (3) in the marine metabolite halichondramide (1) is described.The synthesis features judicious application of the Evans chiral aldol protocol in combination with the controlled ring opening of chiral α-e

Full text of DOI:10.1016/S0040-4039(00)79858-3

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