Tetrahedron Letters p. 3227 - 3230 (1992)
Update date:2022-08-05
Kiefel, Milton J.
Maddock, John
Pattenden, Gerald
A synthesis of the keto-triol formyl enamine moiety (3) in the marine metabolite halichondramide (1) is described.The synthesis features judicious application of the Evans chiral aldol protocol in combination with the controlled ring opening of chiral α-e
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