Ionic liquid catalyzed one-pot synthesis of novel spiro-2-amino-3- phenylsulfonyl-4H-pyran derivatives

Article abstract of DOI:10.1016/j.tetlet.2013.02.073

A series of novel spiro-2-amino-3-phenylsulfonyl-4H-pyran derivatives were synthesized via the three component, one pot reaction of phenylsulfonylacetonitrile and 1,3-dicarbonyl compounds with isatins or acenaphthenequinone in ethanol with a novel basic ionic liquid 2-hydroxyethyl ammonium acetate [H₃N⁺CH₂CH₂OH] [CH₃COO^-] (HEAA) as catalyst. HEAA was found to be a suitable and efficient catalyst for this condensation. This method has some distinct advantages such as mild reaction conditions, short reaction time, and environmental friendliness.