25-Hydroxydihydrotachysterol2. An innovative synthesis of a key metabolite of dihydrotachysterol2

DOI: 10.1016/S0040-4020(01)85618-0

Source and publish data:

Tetrahedron p. 9283 - 9294 (1992)

Update date:2022-08-04

Topics:

Authors:

Hanekamp

Rookhuizen

Bos Bos

Brandsma

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Article abstract of DOI:10.1016/S0040-4020(01)85618-0

A new synthesis of 25-hydroxydihydrotachysterol₂ is described. The hydroxylated side-chain is constructed stereoselectively using a chiral Wittig reagent. The A-ring synthon is introduced utilising the Wittig-Horner method as developed by Lythgoe et al. The preparation of the metabolite is carried out in 18 steps.

Full text of DOI:10.1016/S0040-4020(01)85618-0

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