Research on Chemical Intermediates p. 3337 - 3348 (2018)
Update date:2022-07-29
Topics:
Patil, Audumbar
Salunkhe, Rajashri
Abstract: A highly efficient one-pot three-component synthesis of bis-spiro piperidine and pyrimidine derivatives has been reported by performing the reaction of formaldehyde, aromatic aniline and 1,3-dicarbonyl compounds. This reaction was carried out at room temperature in 2,2,2-trifluoroethanol (TFE) as a recyclable reaction medium under the metal free condition. The strong hydrogen donor ability and acidic property of TFE plays a key role in accelerating the rate of reaction and initiates the reaction smoothly. The advantageous features of this method are a mild reaction condition, no column chromatographic purification, and high yield of products and recyclability of TFE. Graphical Abstract: [Figure not available: see fulltext.].
View MoreContact:+86-571-86217390
Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.
Nanjing distinctions Medical Technology Co., Ltd.(expird)
Contact:+86-15996203785 13914714059
Address:nanjing,jiangsu , China
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)
Contact:+86-21-54159691
Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Yancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Beijing Harmony Chemical Co., Ltd.
Contact:86-010-84956928
Address:Room 207, Jin feng he B building, No 8 Xin Jie Kou Wai Street, Xi Cheng District, Beijing,PRC. 10008
Doi:10.1021/jo4004184
(2013)Doi:10.1016/j.tet.2017.06.064
(2017)Doi:10.1016/S0040-4039(00)92516-4
(1992)Doi:10.1002/poc.797
(2004)Doi:10.1002/chem.201203936
(2013)Doi:10.1021/ol402981z
(2013)