Research on Chemical Intermediates p. 3337 - 3348 (2018)
Update date:2022-07-29
Topics:
Patil, Audumbar
Salunkhe, Rajashri
Abstract: A highly efficient one-pot three-component synthesis of bis-spiro piperidine and pyrimidine derivatives has been reported by performing the reaction of formaldehyde, aromatic aniline and 1,3-dicarbonyl compounds. This reaction was carried out at room temperature in 2,2,2-trifluoroethanol (TFE) as a recyclable reaction medium under the metal free condition. The strong hydrogen donor ability and acidic property of TFE plays a key role in accelerating the rate of reaction and initiates the reaction smoothly. The advantageous features of this method are a mild reaction condition, no column chromatographic purification, and high yield of products and recyclability of TFE. Graphical Abstract: [Figure not available: see fulltext.].
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