Journal of Medicinal Chemistry p. 3455 - 3463 (1993)
Update date:2022-07-30
Topics:
Kelley
Linn
McLean
Tuttle
A series of 9-[(phosphonoalkyl)benzyl]guanines was synthesized and tested for inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase). Inhibitors of PNPase should be T-cell selective, immunosuppressive agents with potential clinical utili
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