Monatshefte fur Chemie p. 647 - 658 (2013)
Update date:2022-09-26
Topics:
Gobis, Katarzyna
Foks, Henryk
Slawinski, Jaroslaw
Sikorski, Artur
Trzybinski, Damian
Augustynowicz-Kopec, Ewa
Napiorkowska, Agnieszka
Bojanowski, Krzysztof
A series of novel heterocyclic sulfonyl-carboximidamides were synthesized in satisfactory yields via condensation of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. New structures were confirmed by IR and NMR spectra as well as elemental analyses. X-ray crystallography of two derivatives was performed. The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. All the compounds were screened for their tuberculostatic, antibacterial, and anticancer activities. Preliminary results indicated that target compounds exhibited weak tuberculostatic and antibacterial activities. Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI 50 values of 0.92-13 μM.
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Doi:10.1002/chem.201201362
(2012)Doi:10.1021/ja00045a016
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(2013)