A short and enantioselective synthesis of (+)-Anatoxin-a

DOI: 10.1016/0040-4039(92)80026-G

Source and publish data:

Tetrahedron Letters p. 3791 - 3794 (1992)

Update date:2022-08-05

Topics:

Authors:

Somfai Somfai

Ahman Ahman

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Article abstract of DOI:10.1016/0040-4039(92)80026-G

A short and enantioselective total synthesis of the neurotoxic alkaloid (+)-Anatoxin-a (1) from the L-pyroglutamic acid derivative 2 is described. The key step involves an intramolecular cyclisation of an N-tosyl iminium ion derived from the corresponding α-methoxy sulfonamide.

Full text of DOI:10.1016/0040-4039(92)80026-G

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