Ambident Behavior of Ketone Enolate Anions in SNAr Substitutions on Fluorobenzonitrile Substrates

DOI: 10.1021/jo00047a008

Source and publish data:

Journal of Organic Chemistry p. 5577 - 5585 (1992)

Update date:2022-09-26

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Authors:

Guedira, Nour-Eddine

Beugelmans, Rene

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Article abstract of DOI:10.1021/jo00047a008

2,6-Difluorobenzonitrile was found to be a suitable substrate for studying carbon versus oxygen nucleophilic attack by enolate anions of weakly acidic ketones.The influence of the nucleophile structure and the solvent are investigated.The charge control character of the reaction and the influence of the substrate are discussed.

Full text of DOI:10.1021/jo00047a008

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