Synthesis and reactions of Biginelli compounds -5. Facile preparation and resolution of a stable 5-dihydropyrimidinecarboxylic acid

DOI: 10.1016/S0040-4020(01)88301-0

Source and publish data:

Tetrahedron p. 5473 - 5480 (1992)

Update date:2022-08-04

Topics:

Authors:

Kappe, C. Oliver

Uray, Georg

Roschger, Peter

Lindner, Wolfgang

Kratky, Christoph

Keller, Walter

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Article abstract of DOI:10.1016/S0040-4020(01)88301-0

The synthesis of enantiomerically pure 5-dihydropyrimidinecarboxylic acids 7a,b is described. Condensation of benzyl acetoacetate with methylurea and 2-naphthaldehyde gave Biginelli compound 3b, which after methylation and removal of the benzyl group led

Full text of DOI:10.1016/S0040-4020(01)88301-0

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