Two effective procedures for the synthesis of trichloromethyl ketones, useful precursors of chiral α-amino and α-hydroxy acids

Article abstract of DOI:10.1016/S0040-4039(00)92656-X

Trichloroacetic acid can be converted to trichloromethyl ketones in good yield by two practical new procedures, one involving the catalyzed reaction of trichloroacetic acid with aldehydes at 23°C followed by oxidation and the other utilizing the coupling