Tetrahedron Letters p. 3919 - 3922 (1992)
Update date:2022-08-03
Topics:
Guanti, Giuseppe
Banfi, Luca
Narisano, Enrica
Riva, Renata
Thea, Sergio
4-(3-hydroxyphenyl)-butanoates 4, on treatment with DIBALH, followed by hydrolytic work-up, undergo a novel completely regioselective intramolecular hydroxyalkylation reaction to give 1,8-dihydroxytetralins.The yield of the reaction depends heavily on the structure of starting material, best results being achieved with 3,3-disubstituted butanoates.
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