Journal of Organic Chemistry p. 5990 - 5994 (1992)
Update date:2022-08-05
Topics:
Taber, Douglass F.
Deker, P. Bruce
Silverberg, Lee J.
Triphenylphosphine/CCl4-mediated cyclization of amino alcohol 17 proceeded smoothly, with single inversion, to provide (-)-indolizidine 223AB 4.Amino alcohol 17 was prepared by thermolysis of azide 16, followed by DIBAL reduction of the intermediate imine.Symchiral aldehyde 12 and phosphonium salt 15, precursors to 16, were prepared by BINAp*Ru*-mediated hydrogenation of the corresponding β-Keto esters.A simplified procedure allows this hydrogenation to be carried out in a Parr shaker, at 80 deg C and 50 psig of H2.
View MoreTaimai Sanluck Pharmaceutical Co.,Ltd
Contact:86-592-7662921
Address:8D,No.186,Huarong Road,Huli,Xiamen,China
HENAN NEW BLUE CHEMICAL CO.,LTD
website:http://www.newbluechem.com
Contact:86-371-55170693/55170694
Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
Contact:86-21 60347964
Address:No.1304, West Meilong Road, Minhang District, Shanghai, China
Chongqing Yawei Fine Chemical Co.,Ltd
Contact:0086-23-62849407
Address:Ziyou village, Nanquan town, Banan district, Chongqing China
Suzhou Health Chemicals Co., Ltd.
website:http://www.healthchems.com
Contact:13776257979
Address:No. 338, Jingang Avenue,
Doi:10.1021/jo00128a018
(1995)Doi:10.1021/ja00048a068
(1992)Doi:10.1021/jo00049a046
(1992)Doi:10.1002/anie.201509465
(2016)Doi:10.1016/0040-4020(92)80021-7
(1992)Doi:10.1002/ejoc.201300026
(2013)
