Journal of Organic Chemistry p. 5990 - 5994 (1992)
Update date:2022-08-05
Topics:
Taber, Douglass F.
Deker, P. Bruce
Silverberg, Lee J.
Triphenylphosphine/CCl4-mediated cyclization of amino alcohol 17 proceeded smoothly, with single inversion, to provide (-)-indolizidine 223AB 4.Amino alcohol 17 was prepared by thermolysis of azide 16, followed by DIBAL reduction of the intermediate imine.Symchiral aldehyde 12 and phosphonium salt 15, precursors to 16, were prepared by BINAp*Ru*-mediated hydrogenation of the corresponding β-Keto esters.A simplified procedure allows this hydrogenation to be carried out in a Parr shaker, at 80 deg C and 50 psig of H2.
View MoreTai zhou world Pharm & Chem Co., Ltd
Contact:+86-576-85301198
Address:Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china
HANGZHOU YUNUO CHEMICAL CO.,LTD
website:http://www.yunuochem.com
Contact:0571-83715115
Address:hangzhou
Contact:+86-913-2223392
Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China
Hefei EnliPharma Tecnology Co.,Ltd
Contact:0086-551-66399836
Address:Qing Cheng ShuiXiang Building 805, Mengcheng North Road , ShuangFeng Economic Development Zone Anhui HeFei
Contact:0550-7041128 0550-7090578
Address:Wangdian Street,Xinjie Town
Doi:10.1021/jo00128a018
(1995)Doi:10.1021/ja00048a068
(1992)Doi:10.1021/jo00049a046
(1992)Doi:10.1002/anie.201509465
(2016)Doi:10.1016/0040-4020(92)80021-7
(1992)Doi:10.1002/ejoc.201300026
(2013)
