Chemical and Pharmaceutical Bulletin p. 59 - 68 (2013)
Update date:2022-08-02
Topics:
Nishimura, Katsumi
Horii, Shinji
Tanahashi, Takao
Sugimoto, Yumi
Yamada, Jun
Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.
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