Journal of the American Chemical Society p. 6600 - 6608 (1993)
Update date:2022-08-05
Topics:
Menger
Chen
Brocchini
Hopkins
Hamilton
Macrocyclic phospholipids containing 32-44 ring atoms were synthesized by a route involving a high-temperature Glaser oxidation as the key step. These lipids are analogous to mammalian phospholipids except a single extra carboncarbon bond joins the chain termini. The new lipids offered, therefore, an opportunity to examine thermotropic properties of their membranes when the chains within a given molecule are unable to move independently of one another. It was concluded that chain "tethering" (a) raises the transition temperatures substantially for all but the shortest lipids, (b) lowers enthalpies of transition by, in part, reducing the number of gauche C-C linkages created during the melting process, and (c) lowers entropies of transition by impeding motional freedom within the liquid-crystalline phase. Molecular mechanics calculations on the macrocyclic lipids are described briefly.
View MoreContact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
Xi'an HO-SHINE Bio-Technology Co., Ltd
Contact:+86 (29) 8248-5435/18292020086
Address:No.6 Shiyuan Road Xian City Shaanxi Province, 710048 China
Taimai Sanluck Pharmaceutical Co.,Ltd
Contact:86-592-7662921
Address:8D,No.186,Huarong Road,Huli,Xiamen,China
Dongguan Albiya Energy Science and Technology Co.,Ltd
Contact:+86-769-22181286
Address:Huanan Industial Park, Dongguan,China
KA-SHING Business Trade Macau Co., Ltd.
Contact:00853-28430045
Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao
Doi:10.1002/chem.201204134
(2013)Doi:10.1080/15533174.2012.754761
(2013)Doi:10.1016/0040-4020(80)88025-2
(1980)Doi:10.1016/j.bmcl.2012.11.103
(2013)Doi:10.1002/anie.201913373
(2020)Doi:10.3906/kim-1204-53
(2013)