Synthesis of a potential 'suicide substrate' of the HIV-1 protease, incorporating a 3-acetoxy-Δ-4,5-(L)-pipecolic acid as proline substitute

Article abstract of DOI:10.1016/S0040-4039(00)60108-9

Coupling of (D,L)-baikiain methyl ester with Boc-(L)-phenylalanine, followed by saponification, iodolactonization and aminolysis of the diastereoisomeric iodolactones by (L)-isoleucyl-(L)-valine methyl ester gave two diastereoisomeric peptides incorporati