Synthesis of isotopically labelled ubiquinones

Article abstract of DOI:10.1016/S0040-4039(00)61251-0

Ubiquinones (1) of various chain lengths have been synthesized. The key step involves the condensation of a long chain polyunsaturated alcohol onto an aromatic intermediate. The synthetic methodology allows for the incorporation of isotopic labels in the methoxy groups attached to the ring portion of the molecule.