The Kondrat'eva reaction in flow: Direct access to annulated pyridines

DOI: 10.1021/ol4013525

Source and publish data:

Organic Letters p. 3550 - 3553 (2013)

Update date:2022-08-05

Topics:

Authors:

Lehmann, Johannes

Alzieu, Thibaut

Martin, Rainer E.

Britton, Robert

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Article abstract of DOI:10.1021/ol4013525

A continuous flow inverse-electron-demand Kondrat'eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chemistry.

Full text of DOI:10.1021/ol4013525

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Product name:4-(4-bromophenyl)-6,7-dihydro-5H-cyclopenta[c]pyridine

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