Journal of Medicinal Chemistry p. 3956 - 3975 (2020)
Update date:2022-08-15
Topics:
Li, Zizhou
Xiao, Senhao
Yang, Yaxi
Chen, Chao
Lu, Tian
Chen, Zhifeng
Jiang, Hualiang
Chen, Shijie
Luo, Cheng
Zhou, Bing
The bromodomain and extra-terminal (BET) family proteins have recently emerged as promising drug targets for cancer therapy. In this study, identification of an 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one fragment (47) as a new binder to the BET bromodomains
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