Collection of Czechoslovak Chemical Communications p. 1516 - 1520 (1992)
Update date:2022-08-04
Topics:
Proksa, Bohumil
Steiner, Bohumil
Uhrinova, Stanislava
Koos, Miroslav
Derivatives of 1-(2-(2-dimethylaminoethyl)benzyliden)isoindolin-3-one underwent deamination on reaction with epoxides under mild conditions.Amide group of the substrate reacted slower with epoxide than the dimethylamino grouping whilst the alkanolamide was formed with a great excess of the epoxide only.Of epoxides used in the reaction 1,2-epoxy-3-phenoxypropane, 3-decyloxy-1,2-epoxypropane and 3-chloro-1,2-epoxypropane, the first was found to react most rapidly.
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Doi:10.1007/s10600-013-0577-1
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